中国药房2025，Vol.36Issue(22)：2815-2821,7.DOI:10.6039/j.issn.1001-0408.2025.22.11
托莱西单抗用于高胆固醇血症患者的成本-效果分析
Cost-effectiveness analysis of tafolecimab in patients with hypercholesterolemia
摘要
Abstract
OBJECTIVE To evaluate the cost-effectiveness of tafolecimab in patients with hypercholesterolemia,and provide support for optimizing management strategies for hypercholesterolemia and healthcare resource allocation.METHODS From the perspective of the Chinese healthcare system,an 11-state mutually exclusive Markov cohort model was developed to simulate disease progression and prognosis in the target population.The model cycle was set to one year,with a 30-year time horizon.Transition probabilities between health states were derived from the CREDIT series of clinical trials,while health utility values and medical cost parameters were sourced from the statistical yearbook and published literature.Quality-adjusted life years(QALYs)were used as the measure of health outcomes.Cost-effectiveness analysis was employed to calculate the incremental cost-effectiveness ratio(ICER)for three dosing regimens of tafolecimab[150 mg every 2 weeks(q2w),450 mg every 4 weeks(q4w),and 600 mg every 6 weeks(q6w)]in combination with statins compared with control therapy(statins).Using 1-3 times the per capita gross domestic product(GDP)of China in 2024 as willingness-to-pay threshold(WTP),with a discount rate of 5%.Model robustness was assessed through one-way sensitivity analysis,probabilistic sensitivity analysis,and scenario analysis.RESULTS The 150 mg q2w regimen of tafolecimab yielded an ICER of 235 827.73 yuan/QALY,which was below the WTP(287 100 yuan/QALY),indicating that the regimen was cost-effective.In contrast,the ICERs for the 450 mg q4w and 600 mg q6w regimens were 329 498.24 and 318 630.51 yuan/QALY,respec-tively,both exceeding the WTP and thus not cost-effective.One-way sensitivity analysis identified the discount rate as a key influencing factor.Probabilistic sensitivity analysis showed that under the WTP set in this study,the probabilities of cost-effectiveness for the 450 mg q4w and 600 mg q6w regimens were 15.3%and 22.4%,respectively,while the 150 mg q2w regimen had an 85.2%probability of being cost-effective.The situational analysis revealed that,over a simulated time horizon of 5 to 30 years,the ICER of tafolecimab was progressively reduced compared with the control regimen.When the price of tafolecimab was lowered by more than 20%,all three dosing regimens were demonstrated to be cost-effective.CONCLUSIONS Under the current Chinese healthcare system,compared with statin monotherapy,tafolecimab(150 mg q2w)combination improves health outcomes in patients with hypercholesterolemia,and is cost-effective given the current WTP.关键词
托莱西单抗/他汀类/高胆固醇血症/成本-效果分析/Markov模型/药物经济学Key words
tafolecimab/statin/hypercholesterolemia/cost-effectiveness analysis/Markov model/pharmacoeconomics分类
药学引用本文复制引用
李彤,张新悦,冯梦文,冯振..托莱西单抗用于高胆固醇血症患者的成本-效果分析[J].中国药房,2025,36(22):2815-2821,7.基金项目
徐州市卫生健康委药学科研立项项目(No.XWYXKY202302) （No.XWYXKY202302）
徐州医科大学附属医院院级科研项目(No.2023ZY01) （No.2023ZY01）
江苏省药学会-恒瑞医院药学基金科研项目(No.H202345) （No.H202345）
