中国药房2025，Vol.36Issue(22)：2862-2867,6.DOI:10.6039/j.issn.1001-0408.2025.22.19
支气管哮喘气道黏液高分泌的发病机制及中药干预研究进展
Research progress on the pathogenesis of airway mucus hypersecretion in bronchial asthma and the intervention of traditional Chinese medicine
摘要
Abstract
Bronchial asthma(abbreviated as asthma)is one of the common chronic airway inflammatory diseases in the respiratory system,which is difficult to cure.Airway mucus hypersecretion(AMH)is an important factor leading to acute asthma attacks.Traditional Chinese medicine(TCM)possesses therapeutic advantages characterized by multiple pathways,multiple targets,and multiple links,and its mechanism of action in intervening in AMH has gradually drawn attention.TCM can effectively alleviate the symptoms of patients by intervening in asthma through methods such as eliminating phlegm and eliminating fluid retention.This review finds that the pathogenesis of asthma-associated AMH is correlated with decreased mucociliary clearance function and enhanced mucus secretion function;single TCM(such as Platycodon grandiflorum),effective components of TCM(such as pinellia polysaccharides),and compound prescriptions(mainly heat-clearing and phlegm-resolving prescriptions,etc.)can improve asthma-associated AMH by regulating the PI3K/Akt and JAK/STAT signaling pathways,inhibiting airway inflammatory responses,oxidative stress,and recovering the water-salt ratio of the mucus layer itself.关键词
支气管哮喘/气道黏液高分泌/中医药/发病机制Key words
bronchial asthma/airway mucus hypersecretion/traditional Chinese medicine/pathogenesis/research progress分类
药学引用本文复制引用
陈瑞怡,春柳,李伟珂,杨菊,王至婉..支气管哮喘气道黏液高分泌的发病机制及中药干预研究进展[J].中国药房,2025,36(22):2862-2867,6.基金项目
国家自然科学基金面上项目(No.81973791) （No.81973791）
河南省中医药科学研究专项课题(No.20-21ZY1020) （No.20-21ZY1020）
