腺苷、腺苷受体和腺苷衍生物在肺部疾病中的作用机制研究进展
Recent advances in roles and mechanisms of adenosine,adenosine receptors,and adenosine derivatives in pulmonary diseases
摘要
Abstract
Adenosine,as a purine nucleoside widely present in living organisms,plays an impor-tant role in such physiological and pathological processes as vasodilation,inflammation regulation,fibrosis,and viral infection.Research has found that in pulmonary hypertension,adenosine acts as a vasodilator through multiple targets.In diseases such as mycoplasma pneumonia,asthma,chronic obstructive pulmonary disease,and idiopathic pulmonary fibrosis,adenosine primarily mediates the progression of inflammation through interactions with adenosine A2A and A2B receptors,thus delivering a dual regulatory effect.This suggests that modulating adenosine receptors is a potential key target for the treatment of pulmonary diseases.Adenosine derivatives-such as acyclovir monophosphate,which has antiviral effects,cyclic adenosine monophosphate,which can alleviate airway narrowing,and N-6-methyladenosine,which is involved in regulating cilia homeostasis and anti-pulmonary fibrosis-are closely related to the occurrence and development of pulmonary diseases.Targeting the adenosine A2A receptor or antagonizing the adenosine A2B receptor can precisely intervene in specific pulmo-nary diseases.Combination medications,regulation of adenosine metabolic pathways,and gene editing technologies promise new treatments.This article reviews the role of adenosine,its receptors,and derivatives in the development of pulmonary diseases in the hopes of providing evidence for related treatment.关键词
腺苷及其受体/腺苷衍生物/肺动脉高压/支原体肺炎/哮喘/慢性阻塞性肺病/特发性肺纤维化Key words
adenosine and its receptors/adenosine derivatives/pulmonary arterial hypertension/mycoplasma pneumonia/asthma/chronic obstructive pulmonary disease/idiopathic pulmonary fibrosis分类
医药卫生引用本文复制引用
钱冰露,袁铖,刘明睿,董佳豪,吴昊,刘应蛟..腺苷、腺苷受体和腺苷衍生物在肺部疾病中的作用机制研究进展[J].中国药理学与毒理学杂志,2025,39(10):790-798,9.基金项目
国家自然科学基金(82360782) （82360782）
江西省自然科学基金(20232BAB206170) （20232BAB206170）
江西省中医药管理局科技计划(2021A333) （2021A333）
江西省卫生健康委科技计划(202211412) （202211412）
江西省"十四五"期间药学一流专业建设经费(2024104-12036) （2024104-12036）
江西中医药大学省级大学生创新创业训练计划(202510412088) National Natural Science Foundation of China(82360782) （202510412088）
Natural Science Foundation of Jiangxi Province(20232BAB206170) （20232BAB206170）
Science and Technology Programs of Jiangxi Provincial Administration of Traditional Chinese Medicine(2021A333) （2021A333）
Jiangxi Province Health and Wellness Commission Science and Technology Program(202211412) （202211412）
Funding for the construction of first-class pharmaceutical programs in Jiangxi Province during the 14th Five-Year Plan period(202410412036) （202410412036）
and Jiangxi University of Traditional Chinese Medicine Provincial College Student Innovation and Entrepreneurship Training Program(202510412088) （202510412088）
