中国医学创新2025，Vol.22Issue(31)：21-24,4.DOI:10.3969/j.issn.1674-4985.2025.31.005
硫酸沙丁胺醇联合小儿定喘口服液治疗小儿轻中度支气管哮喘的效果
Effect of Salbutamol Sulfate Combined with Xiao'er Dingchuan Oral Liquid on Mild to Moderate Bronchial Asthma in Children
冯娟 1梁莉 1周艳菊1
作者信息
- 1. 昆明市第一人民医院儿科 云南 昆明 650000
- 折叠
摘要
Abstract
Objective:To explore the oxidative stress state and treatment efficacy of Salbutamol Sulfate combined with Xiao'er Dingchuan Oral Liquid in the treatment of mild to moderate bronchial asthma in children.Method:From January 2022 to January 2024,80 children with mild to moderate bronchial asthma in Department of Pediatrics,the First People's Hospital of Kunming were selected.According to the random number table method,they were divided into Salbutamol group(40 cases)and combined group(40 cases).The Salbutamol group was treated with Salbutamol Sulfate,and the combined group was treated with Salbutamol Sulfate combined with Xiao'er Dingchuan Oral Liquid.Both groups were treated for one week.The indexes of oxidative stress,inflammatory reaction,treatment efficacy and adverse reactions were compared between the two groups.Result:After treatment,the level of endothelin(ET)in combined group was lower than that in Salbutamol group(P<0.05).After treatment,the level of superoxide dismutase(SOD)in the combined group was higher than that in the Salbutamol group(P<0.05).After treatment,IL-5,TNF-α and leukotriene C4(LTC4)in the combined group were lower than those in the Salbutamol group(P<0.05).The total effective rate of combined group was higher than that of Salbutamol group(P<0.05).There was no significant difference in the incidence of adverse reactions between the combined group and the Salbutamol group(P>0.05).Conclusion:Salbutamol Sulfate combined with Xiao'er Dingchuan Oral Liquid can improve oxidative stress and inflammatory reaction in children with mild and moderate bronchial asthma,improve the therapeutic effect,and does not increase adverse reactions.关键词
硫酸沙丁胺醇/小儿定喘口服液/支气管哮喘/氧化应激状态/炎症反应Key words
Salbutamol Sulfate/Xiao'er Dingchuan Oral Liquid/Bronchial asthma/Oxidative stress state/Inflammatory reaction引用本文复制引用
冯娟,梁莉,周艳菊..硫酸沙丁胺醇联合小儿定喘口服液治疗小儿轻中度支气管哮喘的效果[J].中国医学创新,2025,22(31):21-24,4.
