摘要
Abstract
Objective:To analyze the application effect of neoadjuvant therapy combined with programmed death protein-1(PD-1)inhibitors in patients with locally advanced colorectal cancer.Method:This article was a prospective study.Sixty patients with locally advanced colorectal cancer who were admitted to Department of Oncology Ⅰ,People's Hospital of Yangjiang from June 2023 to January 2025 were selected as the subjects and divided into two groups by the envelope method,with 30 cases in each group.The control group received neoadjuvant chemotherapy with FOLFOX6,and the observation group was treated with PD-1 inhibitor(Sintilimab Injection)on the basis of the control group.The anorectal dynamics,tumor markers and the incidence of toxic and side effects between the two groups were compared.Result:After treatment,the anorectal dynamics levels were improved in both groups,the maximum systolic blood pressure(MSP),anal resting pressure(ARP)and maximum tolerated volume(MTV)in the observation group were larger than those in the control group,and the anorectal inhibitory reflex threshold(AIRT)and rectal resting pressure(RRP)were lower than those in the control group(P<0.05).After treatment,the tumor markers were decreased in both groups,the levels of carbohydrate antigen 19-9(CA19-9),carcinoembryonic antigen(CEA)in the observation group were lower than those in the control group(P<0.05).There was no statistically significant difference in the incidence of toxic and side effects between the two groups(P>0.05).Conclusion:Neoadjuvant therapy combined with PD-1 inhibitors can improve the anorectal dynamics levels of locally advanced colorectal cancer patients,reduce the tumor markers levels,and does not increase the toxic and side effects.关键词
新辅助治疗/程序性死亡蛋白-1抑制剂/局部进展期结直肠癌/肿瘤标志物/肛肠动力学/毒副反应Key words
Neoadjuvant therapy/Programmed death protein-1 inhibitors/Locally advanced colorectal cancer/Tumor markers/Anorectal dynamics/Toxic and side effects
