摘要
Abstract
Objective:To observe and investigate the effect of Paricalcitol combined with Cinacalcet in the treatment of secondary hyperparathyroidism(SHPT)in chronic kidney disease.Method:A total of 80 patients with SHPT in chronic kidney disease diagnosed in Jiujiang Hospital of Traditional Chinese Medicine from January 2022 to January 2025 were selected.The patients were divided into the Paricalcitol group and the combined group by simple random grouping method,with 40 cases in each group.Patients in the Paricalcitol group were treated with Paricalcitol,and those in the combined group were treated with Cinacalcet combined with Paricalcitol.Both groups received continuous treatment for 12 weeks.The clinical efficacy,intact parathyroid hormone(iPTH),parathyroid volume,bone metabolism indicators,bone mineral density,calcium and phosphorus metabolism indicators,and adverse reactions of the two groups were compared.Result:After 12 weeks of treatment,the total effective rate in the combined group was 92.50%,significantly higher than 75.00%in the Paricalcitol group(P<0.05).After 12 weeks of treatment,the iPTH in the combined group was lower than that in the Paricalcitol group,and the parathyroid volume was smaller than that in the Paricalcitol group(P<0.05).After 12 weeks of treatment,the level of alkaline phosphatase(ALP)in the combined group was lower than that in the Paricalcitol group,and the bone mineral density was higher than that in the Paricalcitol group(P<0.05).After 12 weeks of treatment,the levels of blood calcium and blood phosphorus in the combined group were lower than those in the Paricalcitol group,and the product of phosphorus and calcium was lower than that in the Paricalcitol group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Paricalcitol combined with Cinacalcet in the treatment of SHPT in chronic kidney disease can effectively reduce iPTH levels,control calcium and phosphorus metabolism disorders,improve bone metabolism,and has significant clinical effect and good safety.关键词
帕立骨化醇/西那卡塞/慢性肾脏病/继发性甲状旁腺功能亢进症Key words
Paricalcitol/Cinacalcet/Chronic kidney disease/Secondary hyperparathyroidism
