摘要
Abstract
Objective:To explore the effects of Thrombin+Octreotide hemostasis regimen assisted with Propranolol on hemodynamic parameters,FIB and cholinesterase(ChE)in patients with cirrhosis and upper gastrointestinal bleeding.Method:A total of 80 patients with cirrhosis and upper gastrointestinal bleeding in Red Star People's Hospital of Jinggangshan General Hospital were retrospectively enrolled from January 2020 to December 2023.According to different treatment methods,they were divided into control group(35 cases,treated with Octreotide+Thrombin)and observation group(45 cases,treated with Propranolol based on the control group).Both group were treated for 3 days.The total effective rate of treatment,clinical indexes,hemodynamic parameters,FIB,ChE and adverse reactions were compared between the two groups.Result:The total effective rate of treatment in observation group was higher than that in control group(100%vs 91.43%,P<0.05).The blood loss in observation group was less than that in control group,hemostasis time was earlier than that in the control group and length of hospital stay was shorter than that in control group(P<0.05).After treatment,blood flow of portal and splenic veins in observation group were less than those in control group,diameters of portal and splenic veins were smaller than those in control group(P<0.05).After treatment,levels of FIB and ChE in observation group were higher than those in control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Thrombin+Octreotide hemostasis assisted with Propranolol can improve clinical symptoms,promote hemodynamic stability,improve coagulation function and liver synthesis function in patients with cirrhosis and upper gastrointestinal bleeding,which has significant curative effect.关键词
肝硬化/上消化道出血/普萘洛尔/凝血酶/奥曲肽/血流动力学Key words
Cirrhosis/Upper gastrointestinal bleeding/Propranolol/Thrombin/Octreotide/Hemodynamic
