中国医学装备2025，Vol.22Issue(11)：65-69,5.DOI:10.3969/j.issn.1672-8270.2025.11.010
18F-FDG PET/CT在不同组织学分型胸腺上皮肿瘤中的鉴别诊断价值分析
Analysis on value of 18F-FDG PET/CT in differential diagnosis for thymic epithelial tumors of different histological types
摘要
Abstract
Objective:To analyze the differentially diagnostic ability of metabolic parameters of 18F-fluorodeoxyglucose positron-emission tomography/computed tomography(18F-FDG PET/CT)in thymic epithelial tumors(TETs)of different histological types.Methods:A total of 72 patients who underwent 18F-FDG PET/CT examination and were confirmed as TETs before treatment at the Department of Nuclear Medicine of the First Medical Center of Chinese PLA General Hospital between January 2013 to May 2022 were analyzed.The patients were divided into thymic tumor with low risk group(9 cases),thymic tumor with high risk group(15 cases)and thymic cancer group(9 cases)according to histological type.The clinical data of patients were recorded,and the patients were staged according to pathological Masaoka-Koga staging of thymic tumor surgery.The maximum standardized uptake value(SUVmax),average standardized uptake value(SUVmean),metabolic tumor volume(MTV),total lesion glycolysis(TLG)and standardized uptake value ratio(SUVR)of the lesions were recorded respectively.The differences of metabolic parameters of various group were compared.The area under curve(AUC)value of receiver operating characteristic(ROC)curve was used to analyze the diagnostic efficacy of 18F-FDG PET/CT in TETs of different histological types.Results:The results of analyzing each metabolic parameter of three groups indicated that the SUVmax,SUVmean and SUVR values of thymic tumor with high risk group and thymic cancer group were significantly higher than them of thymic tumor with low risk group,and the differences were significant(F=10.315,8.336,11.593,P<0.05),respectively.SUVR has the highest diagnostic efficacy in the differential diagnosis for thymic tumor and thymic cancer(AUC:0.864,sensitivity:83.3%,specificity:75.0%),and for thymic tumor with high-risk and thymic cancer(AUC:0.832,sensitivity:56.3%,specificity:100.0%).In addition,SUVR has the highest diagnostic efficacy for thymic tumor with high-risk and thymic tumor with low-risk(AUC:0.748,sensitivity:80.0%,specificity:66.7%).Conclusion:The metabolic parameters of 18F-FDG PET/CT have a certain of differential and diagnostic value in identifying TETs of different histological types.关键词
胸腺上皮肿瘤(TETs)/代谢参数/18F-氟脱氧葡萄糖正电子发射断层扫描/计算机体层扫描(18F-FDG PET/CT)/诊断价值Key words
Thymic epithelial tumor/Metabolic parameters/18F-fluorodeoxyglucose positron-emission tomography/computed tomography(18F-FDG PET/CT)/Differential diagnosis分类
医药卫生引用本文复制引用
孙亚兵,徐晓丹,孙树伟,宋敬斌,赵东,王观筠,徐白萱,王瑞民..18F-FDG PET/CT在不同组织学分型胸腺上皮肿瘤中的鉴别诊断价值分析[J].中国医学装备,2025,22(11):65-69,5.基金项目
北京市自然科学基金-海淀原始创新联合基金资助项目(L252051) Beijing Natural Science Foundation-Haidian Original Innovation Joint Fund(L252051) （L252051）
