肿瘤防治研究2025，Vol.52Issue(11)：913-925,13.DOI:10.3971/j.issn.1000-8578.2025.25.0508
克服非小细胞肺癌免疫治疗耐药的策略——针对癌细胞
Developing Effective Strategies to Overcome Immunotherapy Resistance in Non-Small Cell Lung Cancer by Directly Targeting Cancer Cells
摘要
Abstract
The development of novel point-to-point drugs targeting resistance mechanisms is a critical and popular research field;nevertheless,success remains challenging.Therefore,given the short survival time and heightened expectations of patients with advanced NSCLC,the design of various combination therapy strategies--integrating preclinical,clinical,and real-world evidence(such as radiotherapy,chemotherapy,targeted therapy,antibody-drug conjugates,oncolytic viruses,and cell therapy)--may be a wise and practical choice to address the disease.Resistance to immunotherapy involves almost all cell types in the body,primarily cancer cells and T cells involved in immune surveillance.As a result of space limitations,this article focuses on the progress and challenges of various combined strategies for directly eliminating cancer cells.We also emphasize the realignment of treatment goals,shifting from primarily focusing on eliminating cancer cells(via chemotherapy and radiotherapy)to fully utilizing immune regulation to over-come resistance to immune checkpoint inhibitors.关键词
非小细胞肺癌/靶向治疗/放疗/化疗/免疫调节Key words
Non-small cell lung cancer/Targeted therapy/Radiotherapy/Chemo-therapy/Immune regulation分类
临床医学引用本文复制引用
黄青,肖嘉祺,胡胜,蔡茜..克服非小细胞肺癌免疫治疗耐药的策略——针对癌细胞[J].肿瘤防治研究,2025,52(11):913-925,13.基金项目
武汉市科技创新基金(2022020801020-513) Wuhan Innovation Fundation(No.2022020801020513) （2022020801020-513）
