肿瘤防治研究2025，Vol.52Issue(11)：926-936,11.DOI:10.3971/j.issn.1000-8578.2025.25.0506
克服非小细胞肺癌中的免疫治疗耐药的策略
Strategies to Overcome Immunotherapy Resistance in Non-Small Cell Lung Cancer:Targeting Non-Cancer Cells
陈润芝 1薛畅 1李小钰 1李远翔 1胡胜1
作者信息
- 1. 430079 武汉,华中科技大学同济医学院附属湖北肿瘤医院肿瘤内科
- 折叠
摘要
Abstract
One of the key mechanisms underlying resistance against immunotherapy is the reduction in the abundance and functional capacity of immune cells within the tumor microenvironment(TME).Accordingly,the development of novel antibodies and small-molecule agents that target multiple co-inhibitory molecules—whether employed as monotherapies or in combination—holds promise for reinvigorating exhausted T cells and restoring antitumor immune responses.In addition,exploring agonists targeting co-stimulatory molecules represents a promising strategy to enhance the secondary signals necessary for T cell activation and thereby facilitates tumor eradication.However,careful attention must be given to potential toxicities associated with these agents.Furthermore,this review highlights the emerging therapeutic potential of cancer vaccines,oncolytic viruses,diverse cellular therapies,and other innovative strategies designed to augment the efficacy of immunotherapy in non-small cell lung cancer(NSCLC).Moreover,we discuss therapeutic strategies targeting non-proliferating TME components,including cancer-associated fibroblasts(CAFs)and the extracellular matrix(ECM),and hypoxia-alleviating agents and immune homeostasis-supporting probiotics,all aimed at enhancing anti-tumor immunity.In summary,this article emphasizes the critical importance of integrating therapeutics with complementary mechanisms of action while maintaining the balance between efficacy and tolerability in the advancement of precise and effective immunotherapy in NSCLC to an unprecedented level.关键词
非小细胞肺癌/免疫检查点抑制剂/细胞治疗/疫苗/生物治疗Key words
Non-small cell lung cancer/Immune checkpoint inhibitor/Cell therapy/Vaccine/Biological therapy分类
临床医学引用本文复制引用
陈润芝,薛畅,李小钰,李远翔,胡胜..克服非小细胞肺癌中的免疫治疗耐药的策略[J].肿瘤防治研究,2025,52(11):926-936,11.
