肿瘤防治研究2025，Vol.52Issue(11)：951-958,8.DOI:10.3971/j.issn.1000-8578.2025.25.0358
从免疫微环境到靶向精准治疗:胰腺癌治疗新策略
From Immune Microenvironment to Targeted Precision Therapy:New Strategies for Treatment of Pancreatic Cancer
摘要
Abstract
Pancreatic cancer is a highly lethal malignancy that is usually diagnosed at an advanced stage because of its absence of early symptoms and lack of effective screening tools.Although existing treatments(e.g.,surgery,chemotherapy,and radiotherapy)can provide temporary relief,the therapeutic effect of pancreatic cancer remains limited,with major issues related to drug resistance and recurrence.In recent years,immunotherapy and targeted therapy have provided renewed hope to the treatment of pancreatic cancer.The immune microenvironment of pancreatic cancer is complex and strongly immunosuppressive.Immune cells such as tumor-associated macrophages and regulatory T cells can weaken the antitumor function of the immune system by secreting inhibitory factors,thereby enabling the tumor to evade immune surveillance.Meanwhile,immune escape is exacerbated by the infiltration of hypo-immune cells and the role of tumor-associated fibroblasts in the tumor microenvironment of pancreatic cancer.In response to these immune escape mechanisms,combining immunotherapy with targeted therapy has emerged as a focal point of current research.This review compiles the characteristics of the immune microenvironment in pancreatic cancer based on current literature,aiming to provide a basis and insights for related drug development.关键词
胰腺癌/肿瘤微环境/免疫治疗/作用机制/精准治疗Key words
Pancreatic cancer/Tumor microenvironment/Immunotherapy/Me-chanism/Precision therapy分类
临床医学引用本文复制引用
余海燕,张火俊..从免疫微环境到靶向精准治疗:胰腺癌治疗新策略[J].肿瘤防治研究,2025,52(11):951-958,8.基金项目
国家自然科学基金面上项目(82272742) （82272742）
上海卫生健康委员会领军人才计划(2022LJ019) National Natural Science Foundation of China(No.82272742) （2022LJ019）
Shanghai Health Commission Talent Program(No.2022LJ019) （No.2022LJ019）
