中兽医医药杂志2025，Vol.44Issue(6)：38-45,8.DOI:10.13823/j.cnki.jtcvm.2025.070
乙酰氨基阿维菌素残留限量及检测方法研究进展
Review on residue limits and detection methods of eprinomectin
摘要
Abstract
Eprinomectin(EPR),as a new generation of derivatives of abamectin drugs,is widely used in animal husbandry,especially in lactating animals,because of its broad-spectrum and efficient anti-parasitic activity and unique low residue characteristics.This paper systematically reviews the research progress of EPR residue limit standard,residue elimination rule in different animal tissues,withdrawal period setting and residue detection technology.China,the United States,the European Union,Japan and other major countries and international organizations have established clear maximum residue limits(MRLs)for EPR in muscle,fat,liver,kidney and milk of cattle,sheep,deer and other animals.Studies have shown that EPR is eliminated slowly in animals,and the withdrawal period varies depending on the type of preparation,route of administration and animal type.It is generally shorter than other avermectins and does not require a period of abandonment.In terms of detection methods,liquid chromatography-tandem mass spectrometry(LC-MS/MS)and high performance liquid chromatography-fluorescence detection(HPLC-FLD)have become mainstream detection methods due to their high sensitivity and accuracy;enzyme-linked immunosorbent assay(ELISA)is suitable for rapid screening,but further confirmation is needed.Although the existing methods are relatively mature,the differences in MRLs between different countries still pose challenges to international trade and regulation.In the future,it is necessary to strengthen the coordination of international standards,promote the innovation of detection technology,and carry out in-depth research on the environmental behavior and ecological risk of EPR to ensure food safety,ecological environment and public health.关键词
乙酰氨基阿维菌素/最大残留限量/药物残留检测/液相色谱-串联质谱/食品安全标准Key words
eprinomectin/maximum residue limit/drug residue detection/liquid chromatography-tandem mass spectrometry/food safety standards分类
农业科技引用本文复制引用
张贺超,白莉霞,葛闻博,刘希望,杨亚军,李剑勇..乙酰氨基阿维菌素残留限量及检测方法研究进展[J].中兽医医药杂志,2025,44(6):38-45,8.基金项目
甘肃省重点研发计划-农业类项目(23YFNA0013) （23YFNA0013）
甘肃省研产融合科技攻关赋能计划-农业领域(25FNNA001) （25FNNA001）
