中医药信息2025，Vol.42Issue(11)：56-61,6.DOI:10.19656/j.cnki.1002-2406.20251109
基于气血理论探讨疏肝活血汤对肝气郁结型围绝经期综合征肠道菌群、神经内分泌功能的影响
Exploring the Effects of Shugan Huoxue Decoction on Intestinal Flora and Neuroendocrine Function in Perimenopausal Syndrome with Liver Qi Stagnation Pattern Based on Qi-Blood Theory
摘要
Abstract
Objective:To investigate the clinical efficacy of Shugan Huoxue Decoction in treating perimenopausal syndrome with liver Qi stagnation pattern based on Qi-Blood Theory,and to explore its effects on intestinal flora and neuroendocrine function.Methods:A total of 114 patients with perimenopausal syndrome of liver Qi stagnation pattern meeting the inclusion criteria at Anyang Traditional Chinese Medicine Hospital were selected and divided into a control group and a Shugan Huoxue group by coin toss method,with 57 cases in each group.The control group received oral venlafaxine treatment,while the Shugan Huoxue group received oral Shugan Huoxue Decoction on the basis of the control group's treatment.Both groups were treated for 8 weeks.The changes in TCM syndrome scores,psychological state(HAMD-17 and SAI scores),intestinal flora levels(Bifidobacterium,Escherichia coli,Enterococcus,Lactobacillus),and neuroendocrine function(TSH,DA,E2,5-HT)were compared between the two groups before and after treatment.The clinical efficacy and incidence of adverse reactions were also compared between the two groups.Results:The total clinical effective rate was 91.23%(52/57)in the Shugan Huoxue group,significantly higher than 77.19%(44/57)in the control group(P<0.05).After 8 weeks of treatment,both groups showed significant reductions in TCM syndrome scores,HAMD-17 scores,SAI scores,Escherichia coli levels,Enterococcus levels,and TSH levels compared with those before treatment(P<0.05),while Bifidobacterium levels,Lactobacillus levels,DA,E2,and 5-HT levels were increased compared with those before treatment(P<0.05).The shugan Huoxue group exerted significantly greater improvement in the aforementioned indicators compared with the control group(P<0.05).Fisher's exact probability test showed that the incidence of adverse reactions was 3.51%(2/57)in the Shugan Huoxue group,with no statistically significant difference compared with 7.02%(4/57)in the control group(P>0.05).Conclusion:Based on Qi-Blood Theory,Shugan Huoxue Decoction can regulate intestinal flora levels,improve psychological state and neuroendocrine function,alleviate clinical symptoms,and demonstrate good safety in treatment of perimenopausal syndrome with liver qi stagnation pattern.关键词
气血理论/疏肝活血汤/围绝经期综合征/肝气郁结/肠道菌群/内分泌功能Key words
Qi-Blood Theory/Shugan Huoxue Decoction/Perimenopausal syndrome/Liver Qi stagnation/Intestinal flora/Endocrine function引用本文复制引用
朱文芳,王苗苗,李光荣..基于气血理论探讨疏肝活血汤对肝气郁结型围绝经期综合征肠道菌群、神经内分泌功能的影响[J].中医药信息,2025,42(11):56-61,6.基金项目
河南省中医药科学研究专项课题(2024ZY2186) （2024ZY2186）
全国名老中医药专家传承工作室建设项目(国中医药人教函[2022]75号) （国中医药人教函[2022]75号）
