中医药信息2025，Vol.42Issue(11)：75-82,8.DOI:10.19656/j.cnki.1002-2406.20251112
干眼炎症相关通路及中医药干预研究进展
Research Progress on Dry Eye Inflammation-Related Pathways and Intervention with Traditional Chinese Medicine
摘要
Abstract
As a prevalent,age-related ocular surface condition with a globally increasing prevalence,dry eye(DE)severely impacts daily work and quality of life.The pathogenesis of DE is complex,and current research primarily focuses on the disruption of the ocular surface microenvironment.Risk factors include apoptosis of corneal and conjunctival epithelial cells,inflammatory responses,and dysfunction of the lacrimal and meibomian glands.This article systematically reviews and summarizes relevant literature on the intervention of traditional Chinese medicine(TCM)in DE-related signaling pathways for treatment.It is found that TCM is widely applied in treating DE,characterized by multi-pathway,multi-target,multi-level regulation,high safety,and minimal side effects.TCM can modulate inflammation-related signaling pathways such as Toll-like receptors(TLR),nuclear factor-κB(NF-κB),NOD-like receptor protein 3/Caspase-1(NLRP3/Caspase-1),mitogen-activated protein kinase/extracellular regulated protein kinase(MAPK/ERK),phosphatidylinositol 3 kinase/protein kinase(PI3K/Akt),adenosine monophosphate-activated protein kinase/silent information regulator 1(AMPK/Sirt1),and mucin 1-human epidermal growth factor receptor 1(MUC1-ErbB1),thereby improving DE symptoms and alleviating disease progression.关键词
中医药/干眼/炎症信号通路/作用机制/研究进展Key words
Traditional Chinese medicine/Dry eye/Inflammatory signaling pathways/Mechanisms of action/Research progress引用本文复制引用
汤博文,罗丹,燕雪晴,李凯..干眼炎症相关通路及中医药干预研究进展[J].中医药信息,2025,42(11):75-82,8.基金项目
全国名老中医药专家传承工作室建设项目(2023YL02604) （2023YL02604）
