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Development,validation,and preliminary phenotypic characterization of a Col6a3 knockout mouse model targeting exon 3

Michel ElChoueiry Harsimran Sidhu Maude Lévesque Dominique Lévesque Jean-François Jacques Otman Sarrhini Jean-François Beaudoin Molly Caron Brenda Gaudette Roger Lecomte Xavier Roucou François-Michel Boisvert Jean-Philippe Brosseau

Animal Models and Experimental Medicine2025，Vol.8Issue(10)：P.1824-1835,12.

Animal Models and Experimental Medicine2025，Vol.8Issue(10)：P.1824-1835,12.DOI:10.1002/ame2.70063

Development,validation,and preliminary phenotypic characterization of a Col6a3 knockout mouse model targeting exon 3

Michel ElChoueiry ¹Harsimran Sidhu ¹Maude Lévesque ¹Dominique Lévesque ²Jean-François Jacques ¹Otman Sarrhini ³Jean-François Beaudoin ³Molly Caron ¹Brenda Gaudette ¹Roger Lecomte ⁴Xavier Roucou ⁵François-Michel Boisvert ⁶Jean-Philippe Brosseau⁵

作者信息

1. Department of Biochemistry and Functional Genomic,Universitéde Sherbrooke,Sherbrooke,Quebec,Canada
2. Department of Immunology and Cellular Biology,Universitéde Sherbrooke,Sherbrooke,Quebec,Canada
3. Centre d''Imagerie Moléculaire de Sherbrooke du Centre de Recherche du Centre Hospitalier,Universitaire de Sherbrooke,Sherbrooke,Quebec,Canada
4. Centre d''Imagerie Moléculaire de Sherbrooke du Centre de Recherche du Centre Hospitalier,Universitaire de Sherbrooke,Sherbrooke,Quebec,Canada Department of Nuclear Medicine and Radiobiology,Universitéde Sherbrooke,Sherbrooke,Quebec,Canada
5. Department of Biochemistry and Functional Genomic,Universitéde Sherbrooke,Sherbrooke,Quebec,Canada Institut de Recherche sur le Cancer de l''Universitéde Sherbrooke,Sherbrooke,Quebec,Canada
6. Department of Immunology and Cellular Biology,Universitéde Sherbrooke,Sherbrooke,Quebec,Canada Institut de Recherche sur le Cancer de l''Universitéde Sherbrooke,Sherbrooke,Quebec,Canada
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摘要

关键词

collagen VI/CRISPR/mass spectrometry/mouse model of human disease/myopathy

分类

医药卫生

引用本文复制引用

Michel ElChoueiry,Harsimran Sidhu,Maude Lévesque,Dominique Lévesque,Jean-François Jacques,Otman Sarrhini,Jean-François Beaudoin,Molly Caron,Brenda Gaudette,Roger Lecomte,Xavier Roucou,François-Michel Boisvert,Jean-Philippe Brosseau..Development,validation,and preliminary phenotypic characterization of a Col6a3 knockout mouse model targeting exon 3[J].Animal Models and Experimental Medicine,2025,8(10):P.1824-1835,12.

基金项目

FRQS,Grant/Award Number:348951。（）

Animal Models and Experimental Medicine

ISSN：2096-5451

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