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A novel biguanide-derivative promotes NEDD4-mediated FGFR1 ubiquitination through BMI1 to overcome osimertinib resistance in NSCLC

Mei Peng Weifan Wang Di Xiao Duo Li Jun Deng Hui Zou Xing Feng Yunhai Yang Songqing Fan Xiaoping Yang

Cancer Biology & Medicine2025，Vol.22Issue(11)：P.1381-1404,24.

Cancer Biology & Medicine2025，Vol.22Issue(11)：P.1381-1404,24.DOI:10.20892/j.issn.2095-3941.2025.0209

A novel biguanide-derivative promotes NEDD4-mediated FGFR1 ubiquitination through BMI1 to overcome osimertinib resistance in NSCLC

Mei Peng ¹Weifan Wang ²Di Xiao ²Duo Li ²Jun Deng ²Hui Zou ²Xing Feng ²Yunhai Yang ³Songqing Fan ⁴Xiaoping Yang²

作者信息

1. Department of Pharmacy and National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University,Changsha 410008,China Department of Oncology,Hunan Provincial People’s Hospital,The First Affiliated Hospital of Hunan Normal University,Changsha 410013,China Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province,Institute of Interdisciplinary Studies,Cancer Institute,School of Pharmaceutical Sciences,Health Science Center,Hunan Normal University,Changsha 410013,China
2. Department of Oncology,Hunan Provincial People’s Hospital,The First Affiliated Hospital of Hunan Normal University,Changsha 410013,China Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province,Institute of Interdisciplinary Studies,Cancer Institute,School of Pharmaceutical Sciences,Health Science Center,Hunan Normal University,Changsha 410013,China
3. Department of Oncological Surgery,Shanghai Chest Hospital,Affiliated to Shanghai Jiaotong University School of Medicine,Shanghai 200030,China
4. Department of Pathology,The Second Xiangya Hospital,Central South University,Changsha 410011,China
折叠

摘要

关键词

NSCLC/biguanide/FGFR1 ubiquitination/BMI1/osimertinib resistance

分类

医药卫生

引用本文复制引用

Mei Peng,Weifan Wang,Di Xiao,Duo Li,Jun Deng,Hui Zou,Xing Feng,Yunhai Yang,Songqing Fan,Xiaoping Yang..A novel biguanide-derivative promotes NEDD4-mediated FGFR1 ubiquitination through BMI1 to overcome osimertinib resistance in NSCLC[J].Cancer Biology & Medicine,2025,22(11):P.1381-1404,24.

基金项目

supported by grants from the National Natural Science Foundation of China(Grant Nos.82172653 and 82472728) （Grant Nos.82172653 and 82472728）

the Key Project of Developmental Biology and Breeding from Hunan Province(Grant No.2022XKQ0205) （Grant No.2022XKQ0205）

the Research Team for Reproduction Health and Translational Medicine of Hunan Normal University(Grant No.2023JC101) （Grant No.2023JC101）

the Natural Science Foundation of Hunan Province(Grant No.2025JJ80150). （Grant No.2025JJ80150）

Cancer Biology & Medicine

ISSN：2095-3941

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