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首页|期刊导航|Acta Biochimica et Biophysica Sinica|Divergent roles of PKM2 in regulating PD-L1 and PD-L2 expression and their implications in human and mouse cancer models

Divergent roles of PKM2 in regulating PD-L1 and PD-L2 expression and their implications in human and mouse cancer models

Shuo He Shujuan Luo Bangwu Cai Jiao Chen Yao Zhang Feng Zhao Qing Liu Tao Liu Wei Wang Tianyuan Peng Xiaomei Lu Shutao Zheng

Acta Biochimica et Biophysica Sinica2025,Vol.57Issue(10):P.1696-1708,13.
Acta Biochimica et Biophysica Sinica2025,Vol.57Issue(10):P.1696-1708,13.DOI:10.3724/abbs.2025019

Divergent roles of PKM2 in regulating PD-L1 and PD-L2 expression and their implications in human and mouse cancer models

Shuo He 1Shujuan Luo 1Bangwu Cai 1Jiao Chen 2Yao Zhang 3Feng Zhao 4Qing Liu 2Tao Liu 5Wei Wang 2Tianyuan Peng 2Xiaomei Lu 2Shutao Zheng1

作者信息

  • 1. State Key Laboratory of Pathogenesis,Prevention,Treatment of Central Asian High Incidence Diseases,Clinical Medical Research Institute,First Affiliated Hospital of Xinjiang Medical University,Xinjiang Uygur Autonomous Region,Urumqi 830011,China Department of Pathology,Basic Medicine College,Xinjiang Medical University,Urumqi 830017,China
  • 2. State Key Laboratory of Pathogenesis,Prevention,Treatment of Central Asian High Incidence Diseases,Clinical Medical Research Institute,First Affiliated Hospital of Xinjiang Medical University,Xinjiang Uygur Autonomous Region,Urumqi 830011,China
  • 3. Beijing Beanstalk International Bilingual School,Beijing,100016
  • 4. State Key Laboratory of Pathogenesis,Prevention,Treatment of Central Asian High Incidence Disease,Operation Management Department,First Affiliated Hospital of Xinjiang Medical University,Xinjiang Uygur Autonomous Region,Urumqi 830011
  • 5. Department of Clinical Laboratory,First Affiliated Hospital of Xinjiang Medical University,Xinjiang Uygur Autonomous Region,Urumqi 830011,China
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摘要

关键词

PKM2/PD-L1/PD-L2/GATA3/immune evasion

分类

医药卫生

引用本文复制引用

Shuo He,Shujuan Luo,Bangwu Cai,Jiao Chen,Yao Zhang,Feng Zhao,Qing Liu,Tao Liu,Wei Wang,Tianyuan Peng,Xiaomei Lu,Shutao Zheng..Divergent roles of PKM2 in regulating PD-L1 and PD-L2 expression and their implications in human and mouse cancer models[J].Acta Biochimica et Biophysica Sinica,2025,57(10):P.1696-1708,13.

基金项目

supported by the grants from the National Natural Science Foundation of China(Nos.82360521 and 82260568) (Nos.82360521 and 82260568)

the Xinjiang Science Fund for Distinguished Young Scholar(No.2022D01E26) (No.2022D01E26)

the Leading Talent Project of Scientific and Technological Innovation in Tianshan Talents Training Plan of Xinjiang Uygur Autonomous Region(No.2022TSYCLJ0031) (No.2022TSYCLJ0031)

the Major Research Project Incubation Program of Xinjiang Medical University(No.XYD2024ZX02) (No.XYD2024ZX02)

the Key Research and Development Project of the Xinjiang Uygur Autonomous Region(No.2020B03003) (No.2020B03003)

the State Key Laboratory of Pathogenesis,Prevention and Treatment of High Incidence Diseases in Central Asia Fund(No.SKL-HIDCA-2024-15) (No.SKL-HIDCA-2024-15)

special funds for the development of local science and technology from the central government(No.ZYYD2022B06) (No.ZYYD2022B06)

the Innovative Team Training Project of the First Affiliated Hospital of Xinjiang Medical University(to X.L.). (to X.L.)

Acta Biochimica et Biophysica Sinica

1672-9145

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