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PDGFC secreted by cancer-associated fibroblasts promotes epithelial-mesenchymal transition and immunosuppression in lung adenocarcinoma

Meimei Cui Xiaodi Ding Yu Jiang Liying Zhang Wangkai Cao Yongming Wang Zhimei Sheng Wei Sun Ai Guo Lihui Gu Xiurong Zhang Wanli Duan Lihong Shi Baogang Zhang

Acta Biochimica et Biophysica Sinica2025，Vol.57Issue(10)：P.1625-1635,11.

Acta Biochimica et Biophysica Sinica2025，Vol.57Issue(10)：P.1625-1635,11.DOI:10.3724/abbs.2025042

PDGFC secreted by cancer-associated fibroblasts promotes epithelial-mesenchymal transition and immunosuppression in lung adenocarcinoma

Meimei Cui ¹Xiaodi Ding ²Yu Jiang ³Liying Zhang ²Wangkai Cao ⁴Yongming Wang ⁴Zhimei Sheng ⁵Wei Sun ⁵Ai Guo ²Lihui Gu ²Xiurong Zhang ⁶Wanli Duan ⁷Lihong Shi ⁸Baogang Zhang⁹

作者信息

1. Department of Clinical Pathology,School of Basic Medicine,Shandong Second Medical University,Weifang 261053,China Department of Pathology,Shaoxing People’s Hospital,Shaoxing 312000,China
2. Department of Clinical Pathology,School of Basic Medicine,Shandong Second Medical University,Weifang 261053,China
3. School of Clinical Medicine,Shandong Second Medical University,Weifang 261053,China
4. Department of Thoracic Surgery,Translational Medical Center,Weifang Second People′s Hospital(Weifang Respiratory Disease Hospital),Weifang 261041,China
5. Affiliated Hospital of Shandong Second Medical University,Weifang 261041,China
6. Key Laboratory of Molecular Pharmacology and Translational Medicine,Shandong Second Medical University,Weifang 261053,China
7. Medical Research Center,Shaoxing People’s Hospital,Shaoxing 312000,China
8. School of Rehabilitation Medicine,Shandong Second Medical University,Weifang 261053,China
9. Department of Pathology,Shaoxing People’s Hospital,Shaoxing 312000,China School of Basic Medicine,Shandong Second Medical University,Weifang 261053,China
折叠

摘要

关键词

cancer-associated fibroblast/platelet-derived growth factor C/lung adenocarcinoma/epithelial-mesenchymal transition/immunosuppression

分类

医药卫生

引用本文复制引用

Meimei Cui,Xiaodi Ding,Yu Jiang,Liying Zhang,Wangkai Cao,Yongming Wang,Zhimei Sheng,Wei Sun,Ai Guo,Lihui Gu,Xiurong Zhang,Wanli Duan,Lihong Shi,Baogang Zhang..PDGFC secreted by cancer-associated fibroblasts promotes epithelial-mesenchymal transition and immunosuppression in lung adenocarcinoma[J].Acta Biochimica et Biophysica Sinica,2025,57(10):P.1625-1635,11.

基金项目

supported by the grants from the National Natural Scientific Foundation of China(Nos.82373124,81872163 and 81672631) （Nos.82373124,81872163 and 81672631）

Wu-Jieping Medical Fund(No.320.6750.2024-21-137) （No.320.6750.2024-21-137）

the Health Science and Technology Development Plan Project of Shandong(No.202101040805) （No.202101040805）

the Weifang Science and Technology Development Program(Nos.2021YX045,2021YX072,2023YX043,2024GX006,2024GX008 and 2024YX043) （Nos.2021YX045,2021YX072,2023YX043,2024GX006,2024GX008 and 2024YX043）

the Scientific and Technological Innovation Team(No.02141607). （No.02141607）

Acta Biochimica et Biophysica Sinica

ISSN：1672-9145

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