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Triptonide facilitates autophagy-mediated apoptosis in esophageal squamous cell carcinoma by targeting the AMPK-mTOR-ULK1 axis

Jiujun Ju Nuo Xu Bohan Li Dan Shi Jiahui Cai Qiusheng Zheng Lei Ye Shaosen Zhang Caixia Wang

Acta Biochimica et Biophysica Sinica2025，Vol.57Issue(10)：P.1611-1624,14.

Acta Biochimica et Biophysica Sinica2025，Vol.57Issue(10)：P.1611-1624,14.DOI:10.3724/abbs.2025056

Triptonide facilitates autophagy-mediated apoptosis in esophageal squamous cell carcinoma by targeting the AMPK-mTOR-ULK1 axis

Jiujun Ju ¹Nuo Xu ¹Bohan Li ¹Dan Shi ¹Jiahui Cai ¹Qiusheng Zheng ¹Lei Ye ¹Shaosen Zhang ²Caixia Wang¹

作者信息

1. Featured Laboratory for Biosynthesis and Target Discovery of Active Components of Traditional Chinese Medicine,School of Traditional Chinese Medicine,Binzhou Medical University,Yantai 264003,China Collaborative Innovation Platform for Modernization and Industrialization of Regional Characteristic Traditional Chinese Medicine,School of Traditional Chinese Medicine,Binzhou Medical University,Yantai 264003,China
2. Department of Etiology and Carcinogenesis,National Cancer Center/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China
折叠

摘要

关键词

triptonide/esophageal squamous cell carcinoma/AMPK-mTOR-ULK1/apoptosis/autophagy

分类

医药卫生

引用本文复制引用

Jiujun Ju,Nuo Xu,Bohan Li,Dan Shi,Jiahui Cai,Qiusheng Zheng,Lei Ye,Shaosen Zhang,Caixia Wang..Triptonide facilitates autophagy-mediated apoptosis in esophageal squamous cell carcinoma by targeting the AMPK-mTOR-ULK1 axis[J].Acta Biochimica et Biophysica Sinica,2025,57(10):P.1611-1624,14.

基金项目

supported by the grants from the National Key R&D Program of China(No.2023YFC3503200 and 2023YFC3503205) （No.2023YFC3503200 and 2023YFC3503205）

the Scientific Research Foundation of Binzhou Medical University(No.BY2020KYQD15). （No.BY2020KYQD15）

Acta Biochimica et Biophysica Sinica

ISSN：1672-9145

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