Acta Biochimica et Biophysica Sinica2025，Vol.57Issue(9)：P.1481-1491,11.DOI:10.3724/abbs.2025052
Causal effects of immune cells on the efficacy and adverse drug reactions of platinum drugs
Wanting Li 1Bing Yu 2Qi Xiao 3Zhao Zhang 4Hanxue Huang 5Jiajia Cui 6Guangying Qi 7Jifang Zheng 7Jiye Yin 3Zhaoqian Liu 3Xi Li 3Howard L.McLeod8
作者信息
- 1. Department of Clinical Pharmacology,Xiangya Hospital,Central South University,Changsha 410008,China Institute of Clinical Pharmacology,Central South University,Hunan Key Laboratory of Pharmacogenetics,Changsha 410008,China Engineering Research Center of Applied Technology of Pharmacogenomics,Ministry of Education,Changsha 410008,China National Clinical Research Center for Geriatric Disorders,Changsha 410008,China Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation,Guilin Medical University,Guilin 541199,China Guangxi Health Commission Key Laboratory of Tumor Immunology and Receptor-Targeted Drug Basic Research,Guilin Medical University,Guilin 541199,China
- 2. Department of Clinical Pharmacology,Xiangya Hospital,Central South University,Changsha 410008,China Institute of Clinical Pharmacology,Central South University,Hunan Key Laboratory of Pharmacogenetics,Changsha 410008,China Engineering Research Center of Applied Technology of Pharmacogenomics,Ministry of Education,Changsha 410008,China National Clinical Research Center for Geriatric Disorders,Changsha 410008,China Department of Pharmacy,Shanghai Children''s Medical Center,School of Medicine,Shanghai Jiao TongUniversity,Shanghai 200120,China
- 3. Department of Clinical Pharmacology,Xiangya Hospital,Central South University,Changsha 410008,China Institute of Clinical Pharmacology,Central South University,Hunan Key Laboratory of Pharmacogenetics,Changsha 410008,China Engineering Research Center of Applied Technology of Pharmacogenomics,Ministry of Education,Changsha 410008,China National Clinical Research Center for Geriatric Disorders,Changsha 410008,China
- 4. Xiangya Medical School,Central South University,Changsha 410013,China
- 5. Department of Clinical Pharmacology,Xiangya Hospital,Central South University,Changsha 410008,China
- 6. Department of Clinical Pharmacology,Xiangya Hospital,Central South University,Changsha 410008,China Institute of Clinical Pharmacology,Central South University,Hunan Key Laboratory of Pharmacogenetics,Changsha 410008,China Engineering Research Center of Applied Technology of Pharmacogenomics,Ministry of Education,Changsha 410008,China
- 7. Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation,Guilin Medical University,Guilin 541199,China Guangxi Health Commission Key Laboratory of Tumor Immunology and Receptor-Targeted Drug Basic Research,Guilin Medical University,Guilin 541199,China
- 8. Department of Clinical Pharmacology,Xiangya Hospital,Central South University,Changsha 410008,China Institute of Clinical Pharmacology,Central South University,Hunan Key Laboratory of Pharmacogenetics,Changsha 410008,China Center for Precision Medicine and Functional Genomics,Utah Tech University,St.George,UT 84770,USA
- 折叠
摘要
关键词
adverse drug reactions/Genome-Wide Association Studies(GWAS)/immune cells/Mendel randomization/platinum drugs分类
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Wanting Li,Bing Yu,Qi Xiao,Zhao Zhang,Hanxue Huang,Jiajia Cui,Guangying Qi,Jifang Zheng,Jiye Yin,Zhaoqian Liu,Xi Li,Howard L.McLeod..Causal effects of immune cells on the efficacy and adverse drug reactions of platinum drugs[J].Acta Biochimica et Biophysica Sinica,2025,57(9):P.1481-1491,11.基金项目
supported by the grants from the National Natural Science Foundation of China(Nos.82173901,82373974,82373962,82073943 and 82204533) （Nos.82173901,82373974,82373962,82073943 and 82204533）
the Major Project of Natural Science Foundation of Hunan Province of China(No.2021 JC0002) （No.2021 JC0002）
the Hunan Province key research and development plan of China(No.2023SK2007) （No.2023SK2007）
the Natural Science Foundation of Hunan Province(No.2023JJ40931). （No.2023JJ40931）
