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NMR-guided rational exploration of co-factors in boosting the Pfu DNA polymerase

Yihao Chen Mingjun Zhu Ruishen Ding Xiaoling Zhao Zhiqing Tao Xu Zhang Maili Liu Lichun He

Magnetic Resonance Letters2025,Vol.5Issue(4):P.49-58,10.
Magnetic Resonance Letters2025,Vol.5Issue(4):P.49-58,10.DOI:10.1016/j.mrl.2025.200218

NMR-guided rational exploration of co-factors in boosting the Pfu DNA polymerase

Yihao Chen 1Mingjun Zhu 2Ruishen Ding 2Xiaoling Zhao 3Zhiqing Tao 2Xu Zhang 2Maili Liu 4Lichun He2

作者信息

  • 1. State Key Laboratory of Magnetic Resonance Spectroscopy and Imaging,National Center for Magnetic Resonance in Wuhan,Innovation Academy for Precision Measurement Science and Technology,Chinese Academy of Sciences,Wuhan,430071,China
  • 2. State Key Laboratory of Magnetic Resonance Spectroscopy and Imaging,National Center for Magnetic Resonance in Wuhan,Innovation Academy for Precision Measurement Science and Technology,Chinese Academy of Sciences,Wuhan,430071,China University of Chinese Academy of Sciences,Beijing,100049,China
  • 3. Department of Reproductive Medicine,General Hospital of Central Theater Command of the People''s Liberation Army,Wuhan,430061,China Qinhe Life Science Ltd.,Wuhan,430000,China
  • 4. State Key Laboratory of Magnetic Resonance Spectroscopy and Imaging,National Center for Magnetic Resonance in Wuhan,Innovation Academy for Precision Measurement Science and Technology,Chinese Academy of Sciences,Wuhan,430071,China University of Chinese Academy of Sciences,Beijing,100049,China Optics Valley Laboratory,Wuhan,430074,China
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摘要

关键词

Pyrococcus furiosus DNA polymerase/Co-factors/NMR spectroscopy

分类

生物科学

引用本文复制引用

Yihao Chen,Mingjun Zhu,Ruishen Ding,Xiaoling Zhao,Zhiqing Tao,Xu Zhang,Maili Liu,Lichun He..NMR-guided rational exploration of co-factors in boosting the Pfu DNA polymerase[J].Magnetic Resonance Letters,2025,5(4):P.49-58,10.

基金项目

supported by the Strategic Priority Research Program of the Chinese Academy of Sciences XDB0540000 ()

Natural Science Foundation of China grants 22327901,22174151 and 21991080 ()

Hubei Provincial Natural Science Foundation of China 2023AFA041。 ()

Magnetic Resonance Letters

2097-0048

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