现代中医临床2025，Vol.32Issue(6)：39-44,6.DOI:10.3969/j.issn.2095-6606.2025.06.008
肛肠坐浴方对高位复杂肛瘘术后早期创面愈合影响的临床研究
Clinical study on the effect of Gangchang Sitting Bath Prescription on early wound healing after surgery for high-position complex anal fistula
摘要
Abstract
Objective To investigate the effect of Gangchang Sitting Bath Prescription on early inflammatory response in patients undergoing high-frequency electric knife high complex anal fistula surgery.Methods Seventy patients who underwent surgery for high-position complex anal fistula at the Department of Anorectal Surgery,Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,from February 2022 to April 2024 were randomly divided into a control group and a treatment group,with 35 patients in each,using a random number table method.The control group received washing treatment with 3%boric acid solution detergent soaking,while the treatment group received washing treatment with Gangchang Sitting Bath Prescription twice a day until the wound was completely healed.Several indicator were observed and compared between two groups on postoperative days 1 and 7,including clinical symptoms of wound exudation,wound pain,and granulation tissue growth,quality of life(QOL)scores,levels of(tumor necrosis factor-α,TNF-α),(interleukin-6,IL-6)in wound secretions and(vascular endothelial growth factor,VEGF)in wound granulation tissue,and the wound healing time.Results On postoperative day 1,there was no statistically significant difference in wound exudation,granulation tissue,and wound pain between the two groups of patients(P>0.05).On postoperative day 7,the wound exudation,granulation tissue,and wound pain scores in the treatment group were lower than those in the control group,and the difference was statistically significant(P<0.01).On postoperative day 1,there was no statistically significant difference in QOL scores between the two groups,including pain,mental state,sleep,and daily life scores(P>0.05).On postoperative day 7,the treatment group had higher scores in pain,mental state,sleep,and daily life than the control group,and the difference was statistically significant(P<0.01).The wound healing time of the treatment group was shorter than that of the control group,and the difference was statistically significant(P<0.01).On postoperative day 1,there was no statistically significant difference in the expression levels of TNF-α,IL-6 in wound secretions and VEGF in wound granulation tissue between the two groups of patients(P>0.05).On postoperative day 7,the levels of TNF-α and IL-6 in wound secretions of the treatment group were lower than those of the control group,and the difference was statistically significant(P<0.01).The expression level of VEGF in wound granulation tissue of the treatment group was higher than that of the control group,and the difference was statistically significant(P<0.01).Conclusion Gangchang Sitting Bath Prescription can reduce early inflammatory response of the wound,accelerate the transition from the inflammatory phase to the proliferative phase,promote the resolution of related clinical symptoms,accelerate the wound healing process,and effectively improve the quality of life of patients after high-frequency electric knife surgery for high-position complex anal fistula.关键词
肛肠坐浴方/高频电刀/高位复杂肛瘘/术后/炎症反应Key words
Gangchang Sitting Bath Prescription/high-frequency electric knife/high-position complex anal fistula/postoperative/inflammatory response分类
医药卫生引用本文复制引用
刘建乔,李宇栋,王亮,刘仍海,张洁,周仲伍,刘子号,芦煜..肛肠坐浴方对高位复杂肛瘘术后早期创面愈合影响的临床研究[J].现代中医临床,2025,32(6):39-44,6.基金项目
中华中医药学会雏鹰计划中医临床青年人才研修项目(No.CYJH2024024) （No.CYJH2024024）
中华中医药学会青年人才托举工程项目(No.CACM-2022-QN-RC2-A03) （No.CACM-2022-QN-RC2-A03）
北京市医院管理中心创新梦工场经费资助(No.202122) （No.202122）
首都医科大学附属北京中医医院职工创新工作室"疑难复杂肛肠疾病术后创面修复"(No.2024-02-C) （No.2024-02-C）
