川北医学院学报2025，Vol.40Issue(11)：1377-1382,6.DOI:10.3969/j.issn.1005-3697.2025.11.004
胃癌组织B3GNT5表达与临床病理参数和预后的相关性研究
Correlation study between B3GNT5 expression in gastric cancer tissues and clinicopathological parameters and prognosis
摘要
Abstract
Objective:To investigate the expression level of B3GNT5 in gastric cancer(GC)tissues and its correlation with clinicopathological parameters and patient prognosis.Methods:The expression difference of B3GNT5 in GC tissues versus adja-cent non-tumor tissues was analyzed using the GEPIA2 database,Kaplan-Meier Plotter database,and TCGA database.Its corre-lation with patient survival was also explored.Tissue samples and clinical data were collected from 85 GC patients.Immunohis-tochemistry(IHC)was used to detect B3GNT5 expression differences between GC tissues and adjacent non-tumor tissues.The correlation between B3GNT5 expression level and the clinicopathological characteristics of GC was analyzed.Results:Bioinfor-matics analysis showed that B3GNT5 was highly expressed in GC tissues and lowly expressed in adjacent non-tumor tissues,with a statistically significant difference(P<0.05).High expression of B3GNT5 was associated with poorer overall survival(OS)and recurrence-free survival(RFS)in GC patients(P<0.05).Pathological IHC revealed that B3GNT5 expression level was higher in GC tissues compared to adjacent non-tumor tissues.B3GNT5 expression level showed correlations with tumor in-vasion depth,lymph node,and TNM stagemetastasis(P<0.05).Kaplan-Meier survival analysis and Cox regression model a-nalysis indicated that B3GNT5 was an independent risk factor for prognosis assessment in GC(P<0.05).Conclusion:High ex-pression of B3GNT5 in gastric cancer is associated with poor prognosis and may serve as a potential biomarker for prognostic assessment in GC.关键词
胃癌/B3GNT5/免疫组化/生物信息学/预后Key words
Gastric cancer/B3GNT5/Immunohistochemistry/Bioinformatics/Prognosis分类
医药卫生引用本文复制引用
金雷,高恬媛,张敏玲,陈传荣..胃癌组织B3GNT5表达与临床病理参数和预后的相关性研究[J].川北医学院学报,2025,40(11):1377-1382,6.基金项目
国家自然科学基金面上项目(82373294) （82373294）
安徽省芜湖市科技局课题项目(2023jc24) （2023jc24）
安徽省芜湖市卫健委科研项目(WHWJ2023y013) （WHWJ2023y013）
