康复学报2025，Vol.35Issue(5)：447-452,462,7.DOI:10.3724/SP.J.1329.2025.05002
帕金森病吞咽障碍康复研究现状和展望
Current Rehabilitation Status and Future Directions of Dysphagia in Parkinson's Disease
摘要
Abstract
Dysphagia in Parkinson's disease(PD)has an insidious onset and worsens progressively,which substantially affects quality of life.The pathogenesis of dysphagia in Parkinson's disease mainly involves degeneration and necrosis of central nervous system neurons,dysfunction of neurotransmitters,and deposition of pathological markers in the peripheral system.Rehabilitation assessments include evaluation of swallowing disorder symptoms(screening scales,clinical evaluation methods,instrument evalua-tion)and evaluation of pathological changes(brain function evaluation based on imaging technology,metabolic evaluation).Rehabili-tation therapy runs through the entire course of Parkinson's disease,in parallel with drug therapy and surgical treatment.The methods mainly include behavioral therapy,instrument-assisted therapy,neural regulation,local injection,and nutritional intervention.Al-though the aforementioned rehabilitation assessment and treatment methods have certain clinical efficacy for dysphagia in Parkin-son's disease,due to the difficulty of early diagnosis of Parkinson's disease,and the pathological mechanism is so complex that cur-rent animal models cannot fully simulate dysphagia in Parkinson's disease,the precise rehabilitation of dysphagia in Parkin-son's disease still needs to combine further basic mechanism research with large-sample clinical studies.This article summarizes the pathogenesis,rehabilitation assessment and treatment methods,current status of basic and clinical research,and future directions of dysphagia in Parkinson's disease,in order to provide a basis for early diagnosis,and standardized prevention and treatment of dys-phagia in Parkinson's disease.关键词
帕金森病/吞咽障碍/发病机制/康复现状/未来方法Key words
Parkinson's disease/dysphagia/pathogenesis/current rehabilitation/future directions引用本文复制引用
张巧俊..帕金森病吞咽障碍康复研究现状和展望[J].康复学报,2025,35(5):447-452,462,7.基金项目
陕西省自然科学基金一般面上项目(2024JC-YBMS-656) （2024JC-YBMS-656）
