保健医学研究与实践2025，Vol.22Issue(8)：65-70,6.DOI:10.11986/j.issn.1673-873X.2025.08.10
原发性肝癌患者血清miR-202、miR-224表达水平与术后复发的关系
Relationship between serum miR-202 and miR-224 expression levels and postoperative recurrence in patients with primary liver cancer
摘要
Abstract
Objective To investigate the relationship between serum miR-202 and miR-224 expression levels and postopera-tive recurrence in patients with primary liver cancer.Methods A total of 156 primary liver cancer patients undergoing radi-cal hepatectomy at Suining Central Hospital(August 2019-August 2022)were assigned to recurrence and non-recurrence groups based on 2-year postoperative recurrence status.General data and serum miR-202/miR-224 expression levels were compared.Receiver operating characteristic(ROC)curves were used to evaluate their predictive value for recurrence,and logistic regression analysis was adopted to identify recurrence risk factors.Results By August 2024,9/156 patients had died;among the remaining 147 patients,45 experienced recurrence and 102 did not.No significant differences were noted in gender,age,BMI,Child-Pugh grade,China Liver Cancer Staging(CNLC),or comorbidities between groups(P＞0.05).The recurrence group showed significantly higher proportions of 2-3 tumors,tumor diameter ≥5 cm,poor tumor differen-tiation,and preoperative AFP ≥400 ng/L(P＜0.05).Serum miR-202 expression was significantly lower while miR-224 was higher in the recurrence group than the non-recurrence group(P＜0.05).ROC analysis showed AUCs of 0.866(95％CI:0.800-0.916)for miR-202 and 0.813(95％CI:0.740-0.872)for miR-224,with sensitivities of 77.78％and 82.22％and specificities of 76.47％and 78.43％,respectively.Multivariate analysis identified miR-202 ≤0.21(OR=3.050,95％CI:1.962-4.740),miR-224 ≥3.00(OR=62.235,95％CI:4.954-781.784),poor differentiation(OR=8.028,95％CI:2.253-28.613),and preoperative AFP ≥400 ng/L(OR=3.127,95％CI:1.079-9.059)as risk factors for postoperative recurrence of primary liver cancer(P＜0.05).Conclusion Serum miR-202 and miR-224 demonstrate high predictive value for postoperative recurrence of primary liver cancer.Low miR-202 expression,high miR-224 expression,poor tumor differentiation,and elevated preoperative AFP are independent risk factors,providing insights for postoperative monitoring and personalized treatment strategies.关键词
原发性肝癌/肝癌根治术/术后复发/miR-202/miR-224/影响因素/预测价值Key words
Primary liver cancer/Radical hepatectomy/Postoperative recurrence/miR-202/miR-224/Influencing factors/Predictive value分类
医药卫生引用本文复制引用
李蓉,刘袁君,刘爽,肖繁,杨旭,张义芳,杨敏..原发性肝癌患者血清miR-202、miR-224表达水平与术后复发的关系[J].保健医学研究与实践,2025,22(8):65-70,6.基金项目
四川省卫生健康委员会科技项目(23LCYJ002). （23LCYJ002）
