吉首大学学报（自然科学版）2025，Vol.46Issue(5)：59-68,10.DOI:10.13438/j.cnki.jdzk.2025.05.009
莱菔子油抗冻伤作用及机制探索
Study on the Effect and Mechanism of Semen Raphani Oil in the Treatment of Chilblains
摘要
Abstract
To investigate the anti-chilblain effect and mechanism of Semen Raphani oil,a mouse chil-blains model was established to observe the effects of Semen Raphani oil on paw swelling rate,pain threshold,and pathological changes in chilblained tissues.Network pharmacology was used to explore the anti-chilblain components,targets,and signaling pathways of Semen Raphani oil.Animal experiments showed that Semen Raphani oil significantly alleviated paw swelling,increased the pain threshold in chil-blained mice,relieved skin edema,and reduced the number of mast cells in chilblained tissues.Network pharmacology predictions indicate that Semen Raphani oil may interact with 38 potential targets in the treatment of chilblains.The core targets include MAOB,HSP90AB1,PTGS2,PTGS1,ACTB,MYC,PGR,NCOA2,RELA,and RXRA.The primary signaling pathways involved are neuroactive ligand signa-ling,chemical carcinogenesis-receptor activation,human cytomegalovirus infection,and the phosphati-dylinositol-3-kinase-protein kinase B(PI3K-Akt)pathway.Key biological functions associated with these targets include smooth muscle contraction,xenobiotic stimulus response,and thermogenesis.关键词
莱菔子油/冻伤/小鼠/作用机制Key words
semen raphani oil/chilblains/mouse/mechanism分类
医药卫生引用本文复制引用
雷艳,靳硕,狄开银,刘昱卉,杨廷,肖雅,徐达,吴光辉..莱菔子油抗冻伤作用及机制探索[J].吉首大学学报（自然科学版）,2025,46(5):59-68,10.基金项目
湘西自治州农科院青年科技创新基金项目(XXNK202440) （XXNK202440）
湖南省现代农业中药材产业技术体系项目(湘农办发[2024]46号) （湘农办发[2024]46号）
