吉首大学学报（自然科学版）2025，Vol.46Issue(5)：69-76,8.DOI:10.13438/j.cnki.jdzk.2025.05.010
微波消融治疗非小细胞肺癌的疗效与不良反应
Efficacy and Adverse Reactions of Microwave Ablation for Non-Small Cell Lung Cancer
摘要
Abstract
Through a search of Chinese and English databases,publicly published articles in domestic and international journals on microwave ablation for the treatment of non-small cell lung cancer were identi-fied.A total of 19 articles were included.A Meta-analysis was conducted to evaluate the efficacy and ad-verse reactions of microwave ablation in the treatment of non-small cell lung cancer as reported in these articles.Trial sequential analysis was then employed to verify the stability of the results in the literature and to calculate the sample size required for consistent results.The results indicated that,compared with radiotherapy and chemotherapy alone,microwave ablation combined with radiotherapy and chemotherapy significantly improved the complete response rate(P＜0.000 01),partial response rate(P=0.01),and overall response rate(P＜0.000 01)of patients,without significantly increasing the incidence of adverse reactions such as myelosuppression(P=0.13),gastrointestinal reactions(P=0.79),and pneumothorax(P=0.43).Regarding the complete response rate and overall response rate,the current research results are consistent.However,for the partial response rate,myelosuppression,gastrointestinal reactions,and pneumothorax,the current research results are inconsistent,and further verification with a larger sample size is still required.关键词
肺癌/微波消融/Meta分析/试验序贯分析Key words
lung cancer/microwave ablation/Meta-analysis/trial sequential analysis分类
医药卫生引用本文复制引用
任圆梦,陆立群,许金红,雷明盛,尚曦..微波消融治疗非小细胞肺癌的疗效与不良反应[J].吉首大学学报（自然科学版）,2025,46(5):69-76,8.基金项目
贵州省科技计划项目(黔科合基础-ZK[2021]一般457) （黔科合基础-ZK[2021]一般457）
贵州省卫生健康委科学技术基金项目(GZWJKJ2020-1-033) （GZWJKJ2020-1-033）
铜仁市科技计划项目(铜市科研[2023]29) （铜市科研[2023]29）
