检验医学与临床2025，Vol.22Issue(22)：3039-3044,6.DOI:10.3969/j.issn.1672-9455.2025.22.003
血清sPD-L1、HIF-1α、PTTG1水平与早期声门型喉癌CO2激光显微手术治疗局部复发的关系
Relationship between serum sPD-L1,HIF-1α and PTTG1 levels with local recurrence after CO2 laser microsurgery in early glottic cancer
摘要
Abstract
Objective To explore the relationship between serum soluble programmed death ligand 1(sPD-L1),hypoxia-inducible factor-1α(HIF-1α)and pituitary tumor transforming gene 1(PTTG1)levels with the local recurrence after CO2 laser microsurgery in early glottic cancer(EGC).Methods A total of 127 patients with EGC who underwent CO2 laser microsurgery in Baoding Municipal First Central Hospital from March 2021 to May 2023 were selected as the EGC group.They were divided into the non-recurrence group and re-currence group based on whether local recurrence occurred after treatment.The other 85 patients with benign laryngeal lesions treated in Baoding Municipal First Central Hospital during the same period were selected as the benign lesion group,and 85 healthy volunteers who underwent physical examinations in Baoding Municipal First Central Hospital during the same period were selected as the control group.The serum PD-L1,HIF-1αand PTTG1 levels in each group were detected by the enzyme-linked immunosorbent assay(ELISA).The multivariate Logistic regression was used to analyze the factors affecting the local recurrence after EGC sur-gery.The receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of serum sPD-L1,HIF-1α and PTTG1 for the local recurrence after EGC surgery.Results The serum sPD-L1,HIF-1αand PTTG1 levels in the EGC group were higher than those in the control group and benign lesion group(P＜0.05).The serum PD-L1,HIF-1α and PTTG1 levels in the benign lesion group were higher than those in the control group(P＜0.05).Among the EGC patients,31 cases had local recurrence after treatment(recurrence group),and 96 cases had no recurrence(non-recurrence group).The serum sPD-L1,HIF-1α and PTTG1 levels in the recurrence group were higher than those in the non-recurrence group(P＜0.05).The results of multi-variate Logistic regression analysis showed that the elevated serum sPD-L1,HIF-1α and PTTG1 levels were the independent risk factors for local recurrence after EGC surgery(P＜0.05).The ROC curve analysis re-sults showed that the areas under the curves(AUCs)of serum sPD-L1,HIF-1α and PTTG1 alone and the their combination for predicting the local recurrence after EGC surgery were 0.846,0.821,0.813 and 0.945 respectively.The AUC of the 3-item combination was greater than that of sPD-L1,HIF-1α and PTTG1 alone(Z=2.649,2.554,2.634,all P＜0.05).Conclusion The serum sPD-L1,HIF-1α and PTTG1 levels in the pa-tients with EGC are up-regulated,which is correlated to the occurrence and postoperative recurrence of EGC.The 3-item combination has a higher predictive value for local recurrence after EGC surgery.关键词
早期声门型喉癌/CO2激光显微手术/可溶性程序性死亡配体1/缺氧诱导因子-1α/垂体肿瘤转化基因1/复发Key words
early glottic cancer/CO2 laser microsurgery/soluble programmed death ligand 1/hy-poxia inducible factor-1α/pituitary tumor transforming gene 1/recurrence分类
医药卫生引用本文复制引用
甄全胜,王立娟,刘冬梅..血清sPD-L1、HIF-1α、PTTG1水平与早期声门型喉癌CO2激光显微手术治疗局部复发的关系[J].检验医学与临床,2025,22(22):3039-3044,6.基金项目
河北省医学科学研究课题计划项目(20242031). （20242031）
