检验医学与临床2025，Vol.22Issue(22)：3045-3049,3055,6.DOI:10.3969/j.issn.1672-9455.2025.22.004
术前PIV、CA199、HPR预测结肠腺瘤高级别上皮内瘤变内镜术后病情进展的价值
Value of preoperative PIV,CA199 and HPR in predicting disease progression after endoscopic surgery in high-grade intraepithelial neoplasia of colon adenoma
摘要
Abstract
Objective To investigate the predictive value of preoperative pan-immune inflammation value(PIV),carbohydrate antigen 199(CA199)and hemoglobin to platelet ratio(HPR)for the disease progression after endoscopic resection in high-grade intraepithelial neoplasia(HGIEN)of colon adenoma.Methods A to-tal of 202 patients with HGIEN of colon adenoma admitted and treated in this hospital from January 2021 to November 2023 were selected as the study subjects and divided into the progression group and non-progression group according to the disease progression in one year after endoscopic surgery.The baseline data,preoperative PIV,CA199 and HPR were compared between the two groups.The multivariate Logistic regression was a-dopted to analyze the influencing factors of postoperative disease progression.The receiver operating charac-teristic(ROC)curve was drawn to analyze the predictive efficiency of preoperative PIV,CA199 and HPR a-lone and their combination for the disease progression after endoscopic surgery in the patients with HGIEN of colon adenoma.Results The proportion of the patients with smoking,proportion of the lesions number ≥3,proportion of villous tubular adenoma among the pathological types in the progression group were higher than those in the non-progression group(P＜0.05).The preoperative PIV and CA199 levels in the progression group were higher than those in the non-progression group,while the HPR level was lower than that in the progression group,and the differences were statistically significant(P＜0.05).The multivariate Logistic re-gression analysis results showed that preoperative PIV increase and CA199 level increase all were the risk fac-tors of the disease progression after endoscopic surgery in the patients with HGIEN of colon adenoma,while the HPR increase was the protective factor of the disease progression after endoscopic surgery in the patients with HGIEN of colon adenoma(P＜0.001).The areas under the curves(AUCs)of preoperative PIV,CA199 and HPR alone and their combination for predicting the disease progression after endoscopic surgery in the pa-tients with HGIEN of colon adenoma were 0.767,0.793,0.760 and 0.950,respectively.The AUC of the 3-i-tem combination for prediction was greater than that of PIV,CA199 and HPR alone(Z=3.474,2.775,3.474,all P＜0.05).Conclusion The preoperative PIV and CA199 levels in the patients with disease progres-sion after endoscopic resection in HGIEN of colon adenoma are increased and HPR is decreased,moreover which are the influencing factors of disease progression after operation.The 3-item combination has the higher predictive value for the disease progression after operation.关键词
结肠腺瘤/高级别上皮内瘤变/泛免疫炎症值/糖类抗原199/血红蛋白/血小板计数/预测价值Key words
colon adenoma/high-grade intraepithelial neoplasia/pan-immune inflammation value/carbohydrate antigen 199/hemoglobin/platelet count/predictive value分类
医药卫生引用本文复制引用
段辉,周政,黄志刚..术前PIV、CA199、HPR预测结肠腺瘤高级别上皮内瘤变内镜术后病情进展的价值[J].检验医学与临床,2025,22(22):3045-3049,3055,6.基金项目
安徽省宣城市卫生健康委员会科研项目(XCWJ2023031). （XCWJ2023031）
