徐敏敏 1徐蕾 1颜超 1侯静 1朱梓瑜 1徐迪 1陈平1
作者信息
- 1. 徐州医科大学附属淮安医院/淮安市第二人民医院检验科,江苏淮安 223000
- 折叠
摘要
Abstract
Objective To study the serum transforming growth factor-β1(TGF-β1),platelet-derived growth factor(PDGF),ferritin(SF)levels and neutrophil-to-lymphocyte ratio(NLR)and albumin-to-fibrinogen ratio(AFR)and their relationship with the prognosis in the patients with acute myeloid leukemia(AML).Methods A total of 192 patients with AML admitted and treated in this hospital from May 2020 to October 2023 were selected as the study group.The other 96 healthy individuals who underwent physical examinations in this hospital during the same period were recruited as the control group.The serum TGF-β1,PDGF and SF levels as well as NLR and AFR were compared between the study group and control group.The patients in the study group were followed up for 12 months after discharge.According to the prognosis,the patients were di-vided into the good prognosis group and poor prognosis group.The clinical data were compared between the two groups.The multivariate Logistic regression was used to analyze the influencing factors of poor prognosis in the patients with AML.The receiver operating characteristic(ROC)curve was drawn to evaluate the pre-dictive value of TGF-β1,PDGF,NLR,AFR and SF for the poor prognosis in the patients with AML.Results The serum TGF-β1 level in the study group was lower than that in the control group(P＜0.05),while the PDGF and SF levels,NLR and AFR were higher than those in the control group(P＜0.05).Among the patients with AML,58 cases had the poor prognosis(poor prognosis group)and 134 cases had the good prognosis(good prognosis group).The serum TGF-β1 level in the good prognosis group was higher than that in the poor prognosis group(P＜0.05),while the PDGF and SF levels,NLR and AFR were lower than those in the poor prognosis group(P＜0.05).The results of multivariate Logistic regression analysis showed that the increased serum PDGF and SF levels,increased NLR and AFR all were the independent risk factors for the poor prognosis in the patients with AML(P＜0.05),and the increased serum TGF-β1 level was an independ-ent protective factor for the poor prognosis in the patients with AML(P＜0.05).The results of ROC curve a-nalysis showed that the areas under the curves(AUCs)of TGF-β1,PDGF,SF,NLR and AFR for predicting the poor prognosis in the patients with AML were 0.744,0.818,0.801,0.780 and 0.842 respectively.Conclu-sion The serum TGF-β1 level in the patients with AML is decreased,while the PDGF and SF levels,NLR and AFR are increased.At the same time,the above indicators all are the independent influencing factors for the poor prognosis in the patients with AML,moreover which have a certain predictive value for their poor prognosis.关键词
急性髓系白血病/转化生长因子-β1/血小板衍生因子/中性粒细胞/淋巴细胞比值/清蛋白/纤维蛋白原比值/铁蛋白Key words
acute myelogenous leukemia/transforming growth factor-β1/platelet-derived growth fac-tor/neutrophil-to-lymphocyte ratio/albumin-to-fibrinogen ratio/ferritin分类
医药卫生
