检验医学与临床2025，Vol.22Issue(22)：3067-3071,5.DOI:10.3969/j.issn.1672-9455.2025.22.008
血清Lp-PLA2、α-syn对精神分裂症患者迟发性运动障碍的诊断价值
Diagnostic value of serum Lp-PLA2 and α-syn for tardive dyskinesia in patients with schizophrenia
摘要
Abstract
Objective To analyze the diagnositc value of serum lipoprotein phospholipase A2(Lp-PLA2)and α-synaptic nuclear protein(α-syn)for tardive dyskinesia(TD)in the patients with schizophrenia.Methods A total of 100 patients with schizophrenia visited in this hospital from November 2021 to November 2022 were selected as the research subjects and divided into the TD group(46 cases)and non-TD group(54 cases)based on whether TD occurred.The serum Lp-PLA2 and α-syn levels and baseline data were compared between the two groups.The multivariate Logistic regression was adopted to analyze the influencing factors for the TD occurrence in schizophrenia patients.The receiver operating characteristic(ROC)curve was drawn to analyze the diagnositc values of serum Lp-PLA2 and α-syn for the TD occurrence in the patients with schiz-ophrenia.Results The serum Lp-PLA2 and α-syn levels in the TD group were higher than those in the non-TD group(P＜0.05).The proportion of cerebral white matter lesions in the TD group was higher than that in the non-TD group,and the serum uric acid(SUA)level was lower than that in the non-TD group(P＜0.05).When the cut-off values of serum Lp-PLA2 and α-syn were 164.38 mg/L and 4.92 μg/L respectively,the are-as under the curves(AUCs)of serum Lp-PLA2 and α-syn for diagnosing the TD occurrence in the patients with schizophrenia were 0.728 and 0.686 respectively,the AUC of the two indicators combination for diagno-sing the TD occurrence was 0.852,which was greater than that of the single indicator(Z=2.768,2.304.both P＜0.05).The results of the multivariate Logistic regression analysis showed that Lp-PLA2 ≥164.38 mg/L,α-syn ≥4.92 μg/L,presence of white matter lesions,and SUA≤358.76 μmol/L all were the risk factors for the TD occurrence in the patients with schizophrenia(P＜0.05).Conclusion Elevated levels of serum Lp-PLA2 and α-syn are closely related to the TD occurrence in the patients with schizophrenia,and the combined detection of serum Lp-PLA2 and α-syn could increase the diagnostic efficiency for the TD occurrence in the pa-tients with schizophrenia,in addition the cerebral white matter lesion existence and SUA≤358.76 μmol/L all are the risk factors for the TD occurrence in the patients with schizophrenia,which should arouse the clinical attention.关键词
脂蛋白磷脂酶A2/α-突触核蛋白/精神分裂症/迟发性运动障碍/血尿酸Key words
lipoprotein phospholipase A2/α-synaptic nuclear protein/schizophrenia/tardive dyski-nesia/serum uric acid分类
医药卫生引用本文复制引用
陈汉华,陈自悦,付远兵,赵金慧..血清Lp-PLA2、α-syn对精神分裂症患者迟发性运动障碍的诊断价值[J].检验医学与临床,2025,22(22):3067-3071,5.基金项目
湖北省卫生健康委员会联合基金项目(WJ2018H0092) （WJ2018H0092）
湖北省武汉市医学科研项目(WZ20Z09). （WZ20Z09）
