检验医学与临床2025，Vol.22Issue(22)：3072-3078,7.DOI:10.3969/j.issn.1672-9455.2025.22.009
舒芬太尼与不同剂量阿芬太尼对气管插管全身麻醉老年患者心血管反应及应激指标的影响
Effects of sufentanil and different doses of alfentanil on cardiovascular response and stress indexes in elderly patients undergoing general anesthesia with tracheal intubation
摘要
Abstract
Objective To explore the effects of sufentanil and different doses of alfentanil on the cardiovas-cular responses and stress indicators in elderly patients undergoing general anesthesia with tracheal intuba-tion.Methods A total of 160 elderly patients undergoing general anesthesia with tracheal intubation in the Seventh Affiliated Hospital of Southern Medical University from October 2023 to October 2024 were selected and divided into 4 groups according to the random number table method,namely the 15,20,25 μg/kg alfen-tanil groups and sufentanil group,40 cases in each group.The 15,20,25 μg/kg alfentanil groups used 15,20,25 μg/kg alfentanil for conducting the anesthesia induction respectively,and the sufentanil group used 0.3μg/kg sufentanil for conducting anesthesia induction.Before anesthesia induction and at 5 min after tracheal intubation,the cardiovascular responses[heart rate(HR),mean arterial pressure(MAP)],stress response in-dicators[norepinephrine(NE)and cortisol(Cor)],cardiac function indicators[cardiac index(CI)and ejec-tion fraction(EF)]and the occurrence situation of adverse reactions of the patients were recorded and com-pared among the groups.Results Before anesthesia induction,there were no statistically significant differ-ences in HR,MAP,NE,Cor,CI and EF among the 4 groups(both P＞0.05).At 5 min after tracheal intuba-tion,HR and MAP in the 15,20,25 μg/kg alfentanil groups were lower than those in the sufentanil group(all P＜0.05),the HR and MAP in the 20,25 μg/kg alfentanil groups were lower than those in the 15 μg/kg al-fentanil group(all P＜0.05),there was no statistically significant difference in HR and MAP between the 20μg/kg alfentanil group and 25 μg/kg alfentanil group(P＞0.05).At 5 min after tracheal intubation,the NE and Cor levels in the 20,25 μg/kg alfentanil groups were lower than those in the sufentanil group(all P＜0.05),the Cor level in the 20 μg/kg alfentanil group and 25 μg/kg alfentanil group were lower than those in the 15 μg/kg alfentanil group(both P＜0.05),however,there was no statistically significant difference in the Cor level between the 20 μg/kg alfentanil group and 25 μg/kg alfentanil group(P＞0.05),there were no sta-tistically significant differences in the NE level among the different doses of alfentanil groups(all P＞0.05).At 5 min after tracheal intubation,CI and EF in the 15,20,25 μg/kg alfentanil groups were lower than those in the sufentanil group(all P＜0.05),the EF in the 20 μg/kg alfentanil group was lower than that in the 15μg/kg alfentanil group(P＜0.05),however,there was no statistically significant difference in EF between the 20 μg/kg alfentanil group and 25 μg/kg alfentanil group(P＞0.05).There was no statistically significant differ-ence in the total incidence rates of adverse reactions among the groups(P＞0.05).Conclusion During the induc-tion period of general anesthesia in elderly patients,intravenous injection of 20 μg/kg alfentanil could more ef-fectively stabilize the cardiovascular responses during tracheal intubation and reduce the levels of stress indica-tors NE and Cor.关键词
气管插管/应激反应/阿芬太尼/舒芬太尼/心血管反应/老年患者Key words
tracheal intubation/stress response/alfentanil/sufentanil/cardiovascular response/elderly patients分类
医药卫生引用本文复制引用
陈莉婷,黄金平,邓玉辉,蔡业华,许平,马长青..舒芬太尼与不同剂量阿芬太尼对气管插管全身麻醉老年患者心血管反应及应激指标的影响[J].检验医学与临床,2025,22(22):3072-3078,7.基金项目
广东省科技计划项目(2014A020213018). （2014A020213018）
