生物质化学工程2025，Vol.59Issue(6)：1-11,11.DOI:10.3969/j.issn.1673-5854.2025.06.001
皂荚多糖基水凝胶的制备及药物缓释应用
Preparation of Saponin Polysaccharide-based Hydrogel and Application of Drug Sustained Release
摘要
Abstract
The aldehyde modification of hydroxyl-rich saponin polysaccharides(GP)could improve the physicochemical properties and enhance their biological activity,which was beneficial to increase their application value.This paper mainly discussed the effect of oxidant dosage and reaction temperature on the properties of aldehyde-modified saponin polysaccharides(DAGP)during the sodium periodate oxidation modification process.The results showed that the mass ratio of oxidizing agent(NaIO4)to GP was 3∶1,and the degree of substitution(Ds)of DAGP7 was as high as 1.77 at 80 ℃ for 4 h.Saponin polysaccharide-based hydrogel(PDG)was prepared by covalent crosslinking with polyvinyl alcohol(PVA),and its structural properties were analyzed by Fourier transform infrared spectroscopy(FT-IR)and X-ray diffraction(XRD).The mechanical properties,rheological characteristics,and release kinetic behavior of rhodamine B(RhB)loaded in aldehyde-modified saponin polysaccharide-based hydrogel was explored in depth.The elongation at break and tensile strength of PDGs prepared after oxidative treatment increased to different degrees.When the ratio of NaIO4 to polysaccharides was 4∶1,the elongation at break of PDG4 reached 1 465％and the tensile strength reached 1.12 MPa.The rheological analysis showed that the prepared hydrogel was an elastic rather than viscous and the crosslinked network structure within the hydrogels remained intact.In the release kinetics behavior of loaded rhodamine B,the cumulative release rate of PGGs was not more than 35％,and the cumulative release rate after modification was as high as 50％,which was 1.48 times that before modification.关键词
皂荚多糖/化学改性/水凝胶/药物释放Key words
saponin polysaccharides/chemical modification/hydrogel/drug delivery分类
化学化工引用本文复制引用
刘新月,冯雅雯,杜楠,姚曦,蒋建新,王堃..皂荚多糖基水凝胶的制备及药物缓释应用[J].生物质化学工程,2025,59(6):1-11,11.基金项目
国家自然科学基金资助项目(32471805) （32471805）
