山东中医药大学学报2025，Vol.49Issue(6)：748-752,804,6.DOI:10.16294/j.cnki.1007-659x.2025.06.009
从"血不利则为水"探讨膜性肾病病机与辨治
Exploration of Pathogenesis,Syndrome Differentiation and Treatment of Membranous Nephropathy from Perspective of"Impaired Blood Circulation Leading to Water Retention"
摘要
Abstract
Membranous nephropathy(MN)is frequently characterized by hypercoagulability as a key pathological feature and edema as the primary clinical manifestation.The associated traits of slowed blood flow and increased thrombotic tendency under hypercoagulable conditions align with the pathogenesis described in traditional Chinese medicine(TCM)as"impaired blood circulation",which denotes a propensity for stasis and stagnation.This paper explores the relationship between hypercoagulability and edema in MN through the TCM principle"impaired blood circulation leads to water retention".We propose that the mutual binding of water and blood stasis constitutes the core pathogenesis underlying MN's development.In treatment,the methods of"invigorating spleen and tonifying kidney to nourish blood and water,removing blood stasis and dredging collaterals to activate blood circulation,and dredging triple energizer to promote diuresis"are adopted to simultaneously regulate blood and water,taking into account both strengthening healthy qi and expelling pathogenic factors,so as to achieve the purpose of activating blood circulation and promoting diuresis without damaging yin and without causing bleeding,provid-ing novel perspectives for TCM-based MN prevention and treatment.关键词
膜性肾病/水肿/血不利则为水/血水同调/健脾补肾/化瘀通络/疏利三焦Key words
membranous nephropathy/edema/impaired blood circulation leads to water retention/simultaneous regulation of blood and water/invigorating spleen and tonifying kidney/removing blood stasis and dredging collaterals/dredging triple energizer分类
医药卫生引用本文复制引用
康意,靳茜,周梦琪,刘玉宁,李丹文,王耀献,吕杰..从"血不利则为水"探讨膜性肾病病机与辨治[J].山东中医药大学学报,2025,49(6):748-752,804,6.基金项目
国家中医药管理局中医药传承与创新"百千万"人才工程项目(批文号:国中医药人教发[2018]12号) （批文号:国中医药人教发[2018]12号）
中央高校基本科研业务费专项(编号:2023-JYB-JBQN-020) （编号:2023-JYB-JBQN-020）
中华中医药学会联合攻关项目(编号:2023DYPLHGG-11) （编号:2023DYPLHGG-11）
