生物医学工程研究2025，Vol.44Issue(5)：311-317,334,8.DOI:10.19529/j.cnki.1672-6278.2025.05.06
基于光学相干弹性成像的巩膜力学特性定量测量
Quantitative measurement of scleral mechanical properties based on optical coherence elastography
摘要
Abstract
To quantitatively measure the mechanical properties of the sclera,we established a sclera shear wave optical coherence elastography(OCE)research platform based on OCE technology,using the piezoelectric stack as the shear wave excitation module and spectral domain optical coherence tomography(SD-OCT)as the motion detection module.Firstly,two scanning modes,M-mode and M-B mode were developed to track the shear wave propagation induced by the piezoelectric stack,achieving non-destructive and high-resolution quantitative analysis of the mechanical properties of different regions of the sclera.Then,experiments on silicone gel mimics,isolated eyeballs and sclera collagen cross-linking were designed.Finally,by systematically comparing the OCE measurement results with the traditional uniaxial mechanical tensile tests,the feasibility and effectiveness of the platform were verified.The experiments on the silicone gel imitation showed that as the Shore hardness of the silicone gel imitation increased,the shear wave velocity also in-creased accordingly.The in vitro eyeball experiment showed that the shear wave velocities on the sclera presented regional differences.Among them,the hardness was the greatest at the equatorial part,followed by the anterior part and the smallest at the posterior part.The scleral collagen cross-linking experiment showed that this method could distinguish the differences in hardening effects caused by different durations of ultraviolet radiation.This research not only provides a new method for evaluating the region-specific mechanical properties of the sclera,but also offers an important technique for studying the pathogenesis of diseases related to scleral biomechanics,such as myopia and glaucoma.关键词
光学相干弹性成像/剪切波/巩膜/生物力学/胶原交联Key words
Optical coherence elastography/Shear waves/Sclera/Biomechanics/Collagen cross-linking分类
医药卫生引用本文复制引用
揭泳,覃茜,张新宇..基于光学相干弹性成像的巩膜力学特性定量测量[J].生物医学工程研究,2025,44(5):311-317,334,8.基金项目
深圳市基础研究项目(JCYJ20190808141605481). （JCYJ20190808141605481）
