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纤维蛋白在恶性肿瘤诊疗中的研究进展

李雁茹刘亮孟玮何秀全朱靖宇

肿瘤预防与治疗2025，Vol.38Issue(11)：1006-1013,8.

肿瘤预防与治疗2025，Vol.38Issue(11)：1006-1013,8.DOI:10.3969/j.issn.1674-0904.2025.11.009

纤维蛋白在恶性肿瘤诊疗中的研究进展

Research Progress on Fibrillarin in the Diagnosis and Treatment of Malig-nant Tumors

李雁茹 ¹刘亮 ²孟玮 ³何秀全 ⁴朱靖宇³

作者信息

1. 261053 山东潍坊,山东第二医科大学临床医学院
2. 250013 济南,山东第一医科大学附属中心医院消化内科
3. 250013 济南,山东第一医科大学附属中心医院内镜中心
4. 250013 济南,山东第一医科大学附属中心医院专科转化研究中心
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摘要

Abstract

Fibrillarin(FBL)is a major nucleolar protein in eukaryotes and a crucial participant in ribosomal biogenesis.Functioning as a methyltransferase,it modifies specific bases on ribosomal RNA through methylation,thereby directly influ-encing the structure and function of rRNA.FBL is involved not only in physiological processes such as ribosomal biogenesis and maturation,apoptosis,cell cycle regulation,and DNA damage repair,but also plays a role in the development and pro-gression of various cancers,where it is closely associated with cancer prognosis.This article reviews recent studies on FBL's role in malignant tumors,aiming to further elucidate its functions in tumorigenesis and progression.The goal is to provide novel strategies for the diagnosis and treatment of these cancers.

关键词

纤维蛋白/恶性肿瘤/核糖体RNA/DNA损伤

Key words

Fibrillarin/Malignant tumor/rRNA/DNA damage

分类

生物科学

引用本文复制引用

李雁茹,刘亮,孟玮,何秀全,朱靖宇..纤维蛋白在恶性肿瘤诊疗中的研究进展[J].肿瘤预防与治疗,2025,38(11):1006-1013,8.

基金项目

山东省自然科学基金(编号:ZR2023ZD41) This study was supported by grants from Science and Technology Department of Shandong Province(No.ZR2023ZD41). （编号:ZR2023ZD41）

肿瘤预防与治疗

ISSN：1674-0904

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