肿瘤预防与治疗2025，Vol.38Issue(11)：1014-1020,7.DOI:10.3969/j.issn.1674-0904.2025.11.010
三阴性乳腺癌铁死亡的代谢途径及治疗研究进展
Research Progress on Metabolic Pathways and Treatment of Ferroptosis in Triple-Negative Breast Cancer
摘要
Abstract
Triple-negative breast cancer(TNBC)is the breast cancer subtype with the highest risk of recurrence and mortality,posing a serious threat to women's health.Ferroptosis is a novel form of regulated cell death characterized by the accumulation of lipid reactive oxygen species and elevated iron levels.The sensitivity of cancer cells to ferroptosis is influ-enced by lipid,iron,and amino acid metabolism.The elevated iron and lipid levels in TNBC present the induction of ferrop-tosis as a promising therapeutic strategy.This review explores the metabolic pathways of ferroptosis in TNBC and related ther-apeutic advances,aiming to provide novel perspectives for improving TNBC treatment outcomes.关键词
三阴性乳腺癌/铁死亡/代谢/治疗Key words
Triple-negative breast cancer/Ferroptosis/Metabolism/Therapy分类
生物科学引用本文复制引用
马成虎,马尚,焦扬驰,李娜,张峰军,胡思畅,孟国文,党政..三阴性乳腺癌铁死亡的代谢途径及治疗研究进展[J].肿瘤预防与治疗,2025,38(11):1014-1020,7.基金项目
兰州市科技计划项目(编号:2024-4-47) This study was supported by grants from Lanzhou Science and Technology Bureau(No.2024-4-47). （编号:2024-4-47）
