妇儿健康导刊2025，Vol.4Issue(22)：83-87,5.DOI:10.3969/j.issn.2097-115X.2025.22.015
血清基础睾酮联合黄体生成素/卵泡刺激素比值对多囊卵巢综合征患者助孕结局的预测价值
Predictive value of serum basal testosterone combined with luteinizing hormone/follicle-stimulating hormone ratio in assisted pregnancy outcomes in patients with polycystic ovary syndrome
摘要
Abstract
Objective To explore the predictive value of serum basal testosterone(T)combined with the ratio of luteinizing hormone/follicle-stimulating hormone(LH/FSH)in assisted-pregnancy outcomes in patients with polycystic ovary syndrome(PCOS).Methods A total of 346 patients with PCOS undergoing in vitro fertilization-embryo transfer for assisted pregnancy in Jinhua People's Hospital were enrolled between February 2020 and December 2024.According to assisted pregnancy outcomes after 4 weeks of in vitro fertilization-embryo transfer,they were divided into pregnancy group(169 cases)and non-pregnancy group(177 cases).The general data,T,LH/FSH ratio and lipid metabolism(total cholesterol[TC],triglyceride[TG],high-density lipoprotein[HDL],and low-density lipoprotein[LDL])in the two groups were compared.After correcting for influence of general data,the relationship between T,LH/FSH ratio and assisted pregnancy outcomes in PCOS patients was analyzed by logistic regression analysis.The predictive value of T,LH/FSH ratio alone and combined detection for assisted pregnancy outcomes was evaluated by receiver operator characteristic curve(ROC)curve.Results The high-quality embryo rate and blastocyst formation rate in the pregnancy group were higher than those in the non-pregnancy group(P<0.05).The T and LH/FSH ratio in pregnancy group were lower than those in non-pregnancy group(P<0.05).There were no statistical differences in levels of HDL,LDL,TC or TG between the two groups(P>0.05).The logistic regression analysis showed that T level and LH/FSH ratio were protective factors for clinical pregnancy in PCOS patients(P<0.05).The AUC of T combined with LH/FSH ratio for predicting assisted pregnancy outcome was the greatest(0.821),higher than that of the individual detection of T or LH/FSH ratio(P<0.05).Conclusion T and LH/FSH ratio can predict assisted pregnancy outcome in patients with PCOS,and combined detection has higher predictive efficiency for assisted pregnancy outcomes.关键词
睾酮/黄体生成素/卵泡刺激素比值/脂代谢/多囊卵巢综合征/助孕结局Key words
Testosterone/Luteinizing hormone/follicle-stimulating hormone ratio/Lipid metabolism/Polycystic ovary syndrome/Assisted pregnancy outcome分类
医药卫生引用本文复制引用
袁爱君,陈梅,王荣..血清基础睾酮联合黄体生成素/卵泡刺激素比值对多囊卵巢综合征患者助孕结局的预测价值[J].妇儿健康导刊,2025,4(22):83-87,5.基金项目
浙江省金华市中医药科学技术研究计划项目(2022KY10). （2022KY10）
