基础医学教育2025，Vol.27Issue(10)：953-958,6.DOI:10.13754/j.issn2095-1450.2025.10.10
基于科研能力培养的医学细胞生物学实验课程设计与实践
Teaching design for the experimental course of medical cell biology based on the cultivation of scientific research ability
摘要
Abstract
Currently,most medical schools teach autophagy-related content in the theoretical course of medical cell biology,yet very few succeed in carrying out autophagy experiments.There is an obvious disconnection between theoretical teaching and experimental teaching,which lags behind disciplinary development.Using genetically modified Caenorhabditis elegans as experimental material,the authors designed a comprehensive experiment to observe cellular autophagy and they recruited students of basic medicine and medical experimental technology to perform open experiments.The gradient-based experimental design features a series of modules of autophagy induction,autophagosome observation and quantification,and investigation of autophagy's effects on lifespan.The authors also ar-ranged after-class activities of group literature review,discussion,and experimental report writing.The authors established a cultiva-tion system of scientific research ability,which is composed of experimental skills,literature reading,and scientific thinking.The teaching reform aims to increase students'enthusiasm,cultivate their research abilities,and enrich teaching content,so that the students can better understand autophagy's significance in biological evolution,laying a solid foundation for their future scientific endeavors.关键词
医学细胞生物学/秀丽隐杆线虫/细胞自噬/实验教学/教学改革/梯度式实验/科研能力Key words
medical cell biology/Caenorhabditis elegans/cellular autophagy/experimental teaching/teaching reform/gra-dient-based experimental design/scientific research ability分类
生物科学引用本文复制引用
张拓,何美娜..基于科研能力培养的医学细胞生物学实验课程设计与实践[J].基础医学教育,2025,27(10):953-958,6.基金项目
国家自然科学基金地区基金资助项目(82260291,82360296,82560299) （82260291,82360296,82560299）
