Identification of a phenyl ester covalent inhibitor of caseinolytic protease and analysis of the ClpP1P2 inhibition in mycobacteria
Genhui Xiao Yan Xia Lan Xu Yu Lu Shawn Chen Yumeng Cui Liangliang Zhou Chuya Niu Bing Wang Jinglan Wang Shaoyang Zhou Miaomiao Pan Chi Kin Chan
微生物（英文）2025，Vol.4Issue(2)：155-168,14.
微生物（英文）2025，Vol.4Issue(2)：155-168,14.DOI:10.1002/mlf2.12169
Identification of a phenyl ester covalent inhibitor of caseinolytic protease and analysis of the ClpP1P2 inhibition in mycobacteria
Identification of a phenyl ester covalent inhibitor of caseinolytic protease and analysis of the ClpP1P2 inhibition in mycobacteria
摘要
关键词
caseinolytic protease/chemical-genetic interaction/drug combination/enzyme inhibitor/mycobacteriaKey words
caseinolytic protease/chemical-genetic interaction/drug combination/enzyme inhibitor/mycobacteria引用本文复制引用
Genhui Xiao,Yan Xia,Lan Xu,Yu Lu,Shawn Chen,Yumeng Cui,Liangliang Zhou,Chuya Niu,Bing Wang,Jinglan Wang,Shaoyang Zhou,Miaomiao Pan,Chi Kin Chan..Identification of a phenyl ester covalent inhibitor of caseinolytic protease and analysis of the ClpP1P2 inhibition in mycobacteria[J].微生物（英文）,2025,4(2):155-168,14.基金项目
This work was supported by the Bill & Melinda Gates Foun-dation(grant number:INV-008249)and GHDDI sponsors in Beijing,China.We thank Dr.Rumin Zhang for the discussion on inhibition kinetics and comments on the manuscript.Drs.Scott Dax and Ying Yuan provided support in the early phase of the project.Special thanks are due to Dr.Nader Fotouhi and the Global Alliance for TB Drug Development for providing the TBac compound library.Dr.Totos Akopian's help with the ClpP enzyme assay is greatly appreciated. （grant number:INV-008249）
