日用化学工业（中英文）2025，Vol.55Issue(10)：1306-1312,7.DOI:10.3969/j.issn.2097-2806.2025.10.011
迷迭香活性成分异迷迭香酚的美白作用及抗氧化活性评价
Evaluation of the whitening effect and antioxidant activity of isorosmanol,an active ingredient of Rosmarinus officinalis L
摘要
Abstract
This study aimed to evaluate the whitening effect and antioxidant activity of isorosmanol,an active ingredient of Rosmarinus officinalis L..The ultraviolet B(UVB)-induced skin photoaging(SP)mouse model was used as the research object,and then three doses(1,2,and 4 mg/cm2)of isorosmanol were transdermally applied to the mice.After 8 weeks of treatment,compared with the UVB group,the epidermal water content in the L-isorosmanol group,the M-isorosmanol group,and the H-isorosmanol group increases the epidermal and dermal morphology improve significantly,the MMP-1 mRNA level decreases,the COL1A1 mRNA level increases,the melanin content,tyrosinase activity,TRP-1 and TRP-2 mRNA relative levels decrease,the α-MSH and MC1R protein relative levels decrease,the SOD,CAT,and GSH-Px activities increase,the MDA content decreases,the Nrf2(nucleus)protein relative level increases,and the Keap1 protein relative level decreases(P<0.05).In conclusion,in UVB-induced SP mice,isorosmanol exerts a whitening effect by inhibiting the α-MSH/MC1R signaling pathway and exerts antioxidant activity by activating the Nrf2/Keap1 signaling pathway.关键词
异迷迭香酚/皮肤光老化/美白/抗氧化/α-MSH/MC1R/Nrf2/Keap1Key words
isorosmanol/skin photoaging/whitening/antioxidant/α-MSH/MC1R/Nrf2/Keap1分类
化学化工引用本文复制引用
郭庆宇,曹丹,陈冬..迷迭香活性成分异迷迭香酚的美白作用及抗氧化活性评价[J].日用化学工业（中英文）,2025,55(10):1306-1312,7.基金项目
徐州市科技局重点研发计划项目(KC23284) （KC23284）
