日用化学品科学2025，Vol.48Issue(11)：17-23,7.DOI:10.3969/j.issn.1006-7264.2025.11.003
十二烷基硫酸钠斑贴建立皮肤舒缓修护模型的评价指标变化规律与稳定性探索
Exploration of variation patterns and stability of evaluation indicators in a sodium lauryl sulfate patch model for skin soothing and repair
摘要
Abstract
Through retrospective data analysis and human studies,this work examined the variation patterns and stability of evaluation indicators in the sodium lauryl sulfate(SLS)patch test model for assessing skin soothing and repair,with the goal of identifying an appropriate evaluation approach.Results showed that EI,TEWL,and TiVi measurements in the 3%SLS patch model demonstrated good modeling stability.Among these indicators,EI and TEWL exhibited significant differences(P<0.05)at D3 and D7 compared with post-modeling baseline values,with consistent differences(P<0.05)in change rates across all time points,reflecting an overall recovery trend within 7 days.In contrast,TiVi values showed no significant differences in either absolute values or rates of change(P>0.05),suggesting a relatively slower recovery pattern.In observational testing,the 3%SLS patch achieved the highest modeling success rate(93%).Data from successful cases revealed similar recovery trends for EI,a*,and TEWL from D1 to D7,while TiVi continued to recover at a slower pace,consistent with retrospective analysis.关键词
十二烷基硫酸钠/人体功效评价/皮肤屏障/损伤模型/舒缓/修护Key words
sodium lauryl sulfate(SLS)/human efficacy evaluation/skin barrier/damage model/skin soothing/skin repair分类
化学化工引用本文复制引用
陈映格,许琦诗,谢安然,王思艺,林小静,孙宇..十二烷基硫酸钠斑贴建立皮肤舒缓修护模型的评价指标变化规律与稳定性探索[J].日用化学品科学,2025,48(11):17-23,7.基金项目
科技部重点研发计划项目——集成化检验检测服务平台研发与应用一站式检验检测服务协同平台示范应用(2018YFB1403305) （2018YFB1403305）
