日用化学品科学2025，Vol.48Issue(11)：25-28,4.DOI:10.3969/j.issn.1006-7264.2025.11.004
3款化妆品体外紧致抗皱功效探究
Investigation of the in vitro firming and anti-wrinkle effects of three cosmetic products
摘要
Abstract
A zebrafish-based evaluation method(UV irradiation model)was established to investigate the firming and anti-wrinkle efficacy of three cosmetic products.The effects of 5,10,and 20 min UV irradiation on the relative mRNA expression of type I collagen genes(col1a1a,col1a1b,col1a2)in AB strain wild-type zebrafish at 6 days post-fertilization(dpf)were examined to determine the optimal modeling conditions.Results showed that 20 min UV irradiation significantly downregulated the expression of all three collagen genes(P<0.05),establishing it as the appropriate condition for the zebrafish UV damage model.Using this model,a 5 g/L concentration of the Firming Lift Cream significantly upregulated col1a2 expression(P<0.05),while a 5 g/L concentration of the Firming Essence significantly upregulated col1a1a and col1a1b expression(P<0.05).Similarly,a 5 g/L concentration of the Firming Wrinkle-Smoothing Essence Water significantly upregulated col1a1a and col1a1b expression(P<0.05).Collectively,all three formulations promoted the expression of one or more type I collagen genes,demonstrating measurable in vitro firming and anti-wrinkle efficacy.These results were consistent with the claimed product functions.关键词
化妆品/斑马鱼/紧致/抗皱/胶原蛋白Key words
cosmetics/zebrafish/firming/anti-wrinkle/collagen分类
化学化工引用本文复制引用
何树锋,李培宁,梁俊杰,李光先,吴剑辉..3款化妆品体外紧致抗皱功效探究[J].日用化学品科学,2025,48(11):25-28,4.基金项目
广州市NQI-质量安全科技协同创新中心(2023B04J0407),广州质量监督检测研究院科技项目(GQT2023KJ01) （2023B04J0407）
