日用化学品科学2025，Vol.48Issue(11)：45-49,5.DOI:10.3969/j.issn.1006-7264.2025.11.008
类神经酰胺的合成方法及碳链长度对配方应用稳定性的影响研究
Synthesis methods of ceramide analogues and the effect of carbon chain length on formulation stability
邱翠萍 1郑华生 1张鹏 1谢培镇 1陈敏杰 1杜克斯2
作者信息
- 1. 广东淼森生物科技股份有限公司,广东 广州 510000
- 2. 广东淼森生物科技股份有限公司,广东 广州 510000||贵州医科大学,贵州 安顺 561000
- 折叠
摘要
Abstract
Starting from hexadecanol,a secondary amine intermediate was synthesized via substitution and dehydration condensation reactions with epoxyhaloalkanes and ethanolamine.Subsequent amidolysis with straight-chain fatty acid methyl esters of varying chain lengths produced ceramide analogues(Cer X1,Cer X2,Cer X3,Cer X4,Cer E)with overall yields exceeding 70%.Structural confirmation was achieved using ¹HNMR,¹³CNMR,and HRMS,while HPLC analysis demonstrated purities above 98.00%.This synthetic route is concise,employs inexpensive and readily available raw materials,operates under mild and safe conditions,and is suitable for industrial-scale production due to its simplicity and high yield.Evaluations of appearance,skin feel,crystal form,and formulation stability revealed that carbon chain length significantly influences application performance.Among the analogues,Cer E,with a hexadecyl chain,exhibited superior formulation stability and optimal adaptability for practical applications.关键词
类神经酰胺/碳链长度/合成/配方稳定性Key words
ceramide analogue/carbon chain length/synthesis/formulation stability分类
化学化工引用本文复制引用
邱翠萍,郑华生,张鹏,谢培镇,陈敏杰,杜克斯..类神经酰胺的合成方法及碳链长度对配方应用稳定性的影响研究[J].日用化学品科学,2025,48(11):45-49,5.
