日用化学品科学2025，Vol.48Issue(11)：50-57,8.DOI:10.3969/j.issn.1006-7264.2025.11.009
特色植物刺山柑果的智能保湿调控机制研究
Research on intelligent moisturizing regulation mechanism of characteristic plant Capparis Spinosa fruit
罗绍强 1魏宁 2周菲 2许余江胜 1刘静华 1卢伊娜2
作者信息
- 1. 海龟爸爸羲和实验室,广东 广州 510700
- 2. 上海珈凯生物股份有限公司,上海 201507
- 折叠
摘要
Abstract
To investigate the intelligent regulation effect and moisturizing mechanism of Capparis Spinosa fruit extract(CS)on skin,a commercial epidermal model was cultured under high and low humidity environments.Multiple detection methods were employed to analyze the epidermal model's structure,cell viability,filaggrin(FLG)regulation,expression levels of related degradation enzymes,natural moisturizing factors content,and skin barrier-associated protein expression.Results demonstrated that CS not only significantly improved cell viability and skin structure under low humidity conditions,but also regulated both FLG synthesis and degradation.At 4 h,CS activated peptidylarginine deiminase 1(PAD1),caspase 14(CASP14),and calpain 1(CAPN1)to increase pyrrolidone carboxylic acid(PCA)and urocanic acid(UCA)levels.By 24 h,CS promoted the production of FLG,loricrin(LOR),zonula occludens-1(ZO-1),PCA,and UCA to maintain skin hydration and barrier function.Therefore,CS exhibits intelligent moisturizing regulation properties,which provided valuable references for its applications in developing cosmetic moisturizing products.关键词
刺山柑果提取物/表皮模型/保湿机理/智能调控Key words
Capparis Spinosa fruit extract/epidermal model/moisturizing mechanism/intelligent regulation分类
化学化工引用本文复制引用
罗绍强,魏宁,周菲,许余江胜,刘静华,卢伊娜..特色植物刺山柑果的智能保湿调控机制研究[J].日用化学品科学,2025,48(11):50-57,8.
