应用化学2025，Vol.42Issue(11)：1461-1471,中插1-中插2,13.DOI:10.19894/j.issn.1000-0518.250174
冷等离子体活化水构建抗菌高分子水凝胶用于皮肤感染创面的修复
Antibacterial Polymer Hydrogel Based on Cold Plasma-Activated Water for Infected Wound Regeneration
摘要
Abstract
The development of advanced wound dressings with high-efficacy antibacterial and tissue regeneration properties is of great significance for the healing of bacterial-infected wounds.Herein,we report a plasma-activated hydrogel(PAH)fabricated by substituting deionized water with plasma-activated water(PAW)during free-radical copolymerization of acrylamide(AM)and N-acryloyl phenylalanine(APhe).The reactive oxygen/nitrogen species(RONS)derived by PAW endowed the hydrogel with excellent antibacterial properties,while the unique three-dimensional network structure and abundant functional groups of the hydrogel provided an ideal matrix for the stable loading of RONS.The PAH exhibited favorable mechanical properties similar to those of skin tissue(Young's modulus of 15.2 kPa,breaking strength of 198 kPa,elongation at break of 1550%),appropriate tissue adhesion(adhesive strength of 6.96 kPa),and excellent biocompatibility and it exhibited high efficiency of proliferation inhibition against Staphylococcus aureus(S.aureus)and Escherichia coli(E.coli),which could meet the critical requirements of infectious wound dressings.In an in-vivo animal model,the PAH showed significant therapeutic effects on S.aureus-infected skin wounds.This work provides a novel strategy for advanced antibacterial dressings,offering a potentially more effective clinical solution for treating wound infection.关键词
水凝胶/冷等离子体活化水/伤口敷料/抗菌Key words
Hydrogel/Cold plasma activated water/Wound dressing/Antibacterial分类
化学化工引用本文复制引用
尚清华,张梦园,郑皓天,赵政,李江涛,成一龙..冷等离子体活化水构建抗菌高分子水凝胶用于皮肤感染创面的修复[J].应用化学,2025,42(11):1461-1471,中插1-中插2,13.基金项目
国家自然科学基金(No.52322309)资助 Supported by the National Natural Science Foundation of China(No.52322309) （No.52322309）
