应用化学2025，Vol.42Issue(11)：1524-1531,8.DOI:10.19894/j.issn.1000-0518.250170
介孔二氧化铈纳米药物载体的制备及促成骨性能
Fabrication of Mesoporous Cerium Dioxide Nanocarriers and Evaluation of Their Osteoinductive Properties
摘要
Abstract
Periodontitis is a chronic inflammatory disease that significantly affects oral health.During its pathological progression,the inflammatory response generates excessive reactive oxygen species(ROS),which disrupts the stability of the tissue microenvironment and impedes bone tissue repair and regeneration.To address these challenges,mesoporous cerium dioxide(CeO2)nanocarriers were synthesized via the hydrothermal method,and metformin(MET)was loaded onto them through physical adsorption to construct CeO2@MET composite nanomaterials.The osteogenic potential of these materials was systematically evaluated.Experimental results demonstrated that CeO2@MET exhibited a uniform mesoporous structure with a MET loading capacity of(5.61±0.37)%(mass fraction).It retained the cubic fluorite structure and oxygen vacancies(Ce3+content of 12.28%)characteristic of CeO2,while displaying excellent antioxidant enzyme activity and sustained drug-release properties.At concentrations of≤100 μg/mL,CeO2@MET significantly promoted the proliferation and migration of MC3T3-E1 pre-osteoblasts and enhanced their alkaline phosphatase activity expression,thereby confirming its excellent biocompatibility and osteogenic differentiation ability.This study successfully developed a CeO2@MET nanocomposite system with dual functionalities of efficient ROS scavenging and controlled drug release.This system achieves synergistic effects in ROS scavenging and MET-induced osteogenesis,offering a novel nanomaterial-based strategy for overcoming bone regeneration obstacles in periodontitis.It holds significant promise for applications in periodontal tissue engineering,combining anti-inflammatory regulation with highly efficient osteogenic activity.关键词
二氧化铈/二甲双胍/介孔/活性氧清除/成骨活性Key words
Cerium dioxide/Metformin/Mesoporous/Reactive oxygen species scavenging/Osteogenic activity分类
化学化工引用本文复制引用
徐殿航,方蛟,王林..介孔二氧化铈纳米药物载体的制备及促成骨性能[J].应用化学,2025,42(11):1524-1531,8.基金项目
吉林省科技厅重点研发项目(No.20230203086SF)和国家自然科学基金青年科学基金项目(No.82301132)资助 Supported by the Key Program of Natural Science Foundation of Jilin Province(No.20230203086SF)and the Young Scientists Fund of the National Science Foundation of China(No.82301132) （No.20230203086SF）
