中国光学（中英文）2025，Vol.18Issue(6)：1316-1326,11.DOI:10.37188/CO.2025-0048
基于差分时间数字转换光子计数技术的时域扩散光学成像系统研究
A time-domain diffuse optical imaging system based on differential time-to-digital converter photon-counting technology
摘要
Abstract
Time-domain diffuse optical imaging(TD-DOI)is an advanced tissue optical imaging technique.Utilizing a time-correlated single-photon counting(TCSPC)system,it enables the quantitative reconstruc-tion of tissue absorption and scattering coefficients.This facilitates the precise assessment of key physiolo-gical parameters,such as tissue oxygen metabolism and blood perfusion.However,due to the inherent hard-ware complexity and high cost of TCSPC systems,it is currently challenging to meet the requirements for scaled,multichannel,dynamic in vivo monitoring in clinical settings.This paper develops a dual-channel dif-ferential hybrid trigger and reference signal strategy.By integrating a differential time-to-digital converter(TDC)device with photon counting technology,we construct a stable and reliable time point spread function(TPSF)measurement system.This system achieves sub-nanosecond precision in calibrating the time delay between the laser synchronization signal and emitted photon signals.Experimental validation demonstrates a system temporal resolution of 55 ps.At a photon count rate of 2.3×104 photons per second,the TPSF fluctu-ation coefficient remains below 1.35%(with an integration time of 1 s).Optical parameter inversion tests on tissue-simulating phantoms demonstrate average inversion errors of 5.39%for the absorption coefficient and 4.34%for the reduced scattering coefficient.This technological approach significantly advances the feasibil-ity of multichannel parallel detection for TD-DOI.It is particularly suitable for biomedical applications de-manding dynamic monitoring,such as cerebral cortical hemoglobin oxygen saturation,and lays the technical groundwork for developing next-generation wearable optical brain functional imaging devices.关键词
时域扩散光学成像/时间相关单光子计数/时间数字转换/光学参数反演Key words
time domain diffuse optical imaging/time-correlated single photon counting/time-to-digital con-verter/optical properties inversion分类
数理科学引用本文复制引用
刘欣霖,路光达,秦转萍,郭庭航,刘东远,高峰..基于差分时间数字转换光子计数技术的时域扩散光学成像系统研究[J].中国光学（中英文）,2025,18(6):1316-1326,11.基金项目
国家自然科学基金(No.62205239,No.62075156) （No.62205239,No.62075156）
中国博士后自然科学基金(No.2023M732600) （No.2023M732600）
天津市信息传感与智能控制重点实验室开放基金课题(No.2023KFJJ02)Supported by the National Natural Science Foundation of China(No.62205239,No.62075156) （No.2023KFJJ02）
China Postdoctoral Science Foundation(No.2023M732600) （No.2023M732600）
Open Fund Project of Tianjin Key Laboratory of In-formation Sensing and Intelligent Control(No.2023KFJJ02) （No.2023KFJJ02）
