中国实验动物学报2025，Vol.33Issue(10)：1522-1530,9.DOI:10.3969/j.issn.1005-4847.2025.10.013
特发性肺纤维化实验模型构建现状与应用进展
Current status and application advances in experimental models of idiopathic pulmonary fibrosis
摘要
Abstract
Idiopathic pulmonary fibrosis(IPF)is a fatal interstitial lung disease characterized by progressive scarring of the lung parenchyma,often result ing in death from respiratory failure in its terminal stages,with a median survival of only 3 to 5 years.Experimental models are essential tools for investigating the pathogenesis of IPF,screening potential drugs,and evaluating therapeutic efficacy.In addition to animal and cell models,the recent development of precision medicine and multi-omics technologies has increased attention on the need to establish models that integrate traditional Chinese medicine(TCM)syndromes with disease patterns,as well as emerging organoid models.IPF experimental models have evolved from simulating a single pathological aspect to multidimensional models that integrate genetic heterogeneity,microenvironment interactions,and the TCM pathophysiological mechanisms of"phlegm,stasis,deficiency,and collateral damage".This systematic review considers the strategies used to construct IPF experimental models,the detection indicators,TCM syndrome research,and evaluation systems,with the aim of providing a reference for IPF-related research.关键词
特发性肺纤维化/动物模型/病证结合/体外模型Key words
idiopathic pulmonary fibrosis/animal models/integration of disease and syndrome/in vitro models分类
生物科学引用本文复制引用
朱梦杰,丁文俊,冯天照,杨彦..特发性肺纤维化实验模型构建现状与应用进展[J].中国实验动物学报,2025,33(10):1522-1530,9.基金项目
四川省中医药管理局科技专项(2024MS601).Funded by Science and Technology Special Project of Sichuan Provincial Administration of Traditional Chinese Medicine(2024MS601). （2024MS601）
