中国实验动物学报2025，Vol.33Issue(10)：1531-1538,8.DOI:10.3969/j.issn.1005-4847.2025.10.014
慢性血栓栓塞性肺动脉高压大鼠模型研究进展
Research progress on rat model of chronic thromboembolic pulmonary hypertension
摘要
Abstract
Chronic thromboembolic pulmonary hypertension(CTEPH)is a severe form of pulmonary hypertension(PH),and is classified as the fourth major category of pulmonary arterial hypertension.CTEPH is primarily caused by chronic thrombosis,leading to the obstruction of blood flow in the pulmonary arteries and result ing in a sustained increase in pulmonary artery pressure.The unclear pathogenesis of CTEPH,however,means that its early diagnosis is challenging,treatment options are limited,and prognosis assessment is often inaccurate.In-depth research into these mechanisms will thus improve our understanding of the pathophysiological processes of CTEPH,and also provide a theoretical basis for developing new therapeutic strategies.This review focuses on the current method of establishing CTEPH rat models and their advantages and disadvantages,offering researchers a reference for selecting and constructing CTEPH rat models.关键词
CTEPH/造模方法/大鼠模型/研究进展Key words
CTEPH/modeling method/rat model/research progress分类
生物科学引用本文复制引用
刘学凯,钟祥,张娟娟,孙小龙,吴盼,庞振川,谢萍..慢性血栓栓塞性肺动脉高压大鼠模型研究进展[J].中国实验动物学报,2025,33(10):1531-1538,8.基金项目
甘肃省2024年度第五批省级科技计划(联合科研基金)项目(24JRRA886).Funded by 2024 Gansu Province 5th Batch of Provincial Science and Technology Plan(Joint Research Fund)Project(24JRRA886). （联合科研基金）
